Global estimates on the number of people blind or visually impaired by age-related macular degeneration: a meta-analysis from 2000 to 2020

Vision Loss Expert Group of the Global Burden of Disease Study; the GBD 2019 Blindness and Vision Impairment Collaborators

doi:10.1038/s41433-024-03050-z

Global estimates on the number of people blind or visually impaired by age-related macular degeneration: a meta-analysis from 2000 to 2020

Vision Loss Expert Group of the Global Burden of Disease Study, the GBD 2019 Blindness and Vision Impairment Collaborators

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

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Abstract

Background: We aimed to update estimates of global vision loss due to age-related macular degeneration (AMD). Methods: We did a systematic review and meta-analysis of population-based surveys of eye diseases from January, 1980, to October, 2018. We fitted hierarchical models to estimate the prevalence of moderate and severe vision impairment (MSVI; presenting visual acuity from <6/18 to 3/60) and blindness (< 3/60) caused by AMD, stratified by age, region, and year. Results: In 2020, 1.85 million (95%UI: 1.35 to 2.43 million) people were estimated to be blind due to AMD, and another 6.23 million (95%UI: 5.04 to 7.58) with MSVI globally. High-income countries had the highest number of individuals with AMD-related blindness (0.60 million people; 0.46 to 0.77). The crude prevalence of AMD-related blindness in 2020 (among those aged ≥ 50 years) was 0.10% (0.07 to 0.12) globally, and the region with the highest prevalence of AMD-related blindness was North Africa/Middle East (0.22%; 0.16 to 0.30). Age-standardized prevalence (using the GBD 2019 data) of AMD-related MSVI in people aged ≥ 50 years in 2020 was 0.34% (0.27 to 0.41) globally, and the region with the highest prevalence of AMD-related MSVI was also North Africa/Middle East (0.55%; 0.44 to 0.68). From 2000 to 2020, the estimated crude prevalence of AMD-related blindness decreased globally by 19.29%, while the prevalence of MSVI increased by 10.08%. Conclusions: The estimated increase in the number of individuals with AMD-related blindness and MSVI globally urges the creation of novel treatment modalities and the expansion of rehabilitation services.

Original language	English
Pages (from-to)	2070-2082
Number of pages	13
Journal	Eye (Basingstoke)
Volume	38
Issue number	11
DOIs	https://doi.org/10.1038/s41433-024-03050-z
Publication status	Published - 09 Mar 2024

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@article{4c2a727ffdb346a28b140f08ffb7af39,

title = "Global estimates on the number of people blind or visually impaired by age-related macular degeneration: a meta-analysis from 2000 to 2020",

abstract = "Background: We aimed to update estimates of global vision loss due to age-related macular degeneration (AMD). Methods: We did a systematic review and meta-analysis of population-based surveys of eye diseases from January, 1980, to October, 2018. We fitted hierarchical models to estimate the prevalence of moderate and severe vision impairment (MSVI; presenting visual acuity from <6/18 to 3/60) and blindness (< 3/60) caused by AMD, stratified by age, region, and year. Results: In 2020, 1.85 million (95%UI: 1.35 to 2.43 million) people were estimated to be blind due to AMD, and another 6.23 million (95%UI: 5.04 to 7.58) with MSVI globally. High-income countries had the highest number of individuals with AMD-related blindness (0.60 million people; 0.46 to 0.77). The crude prevalence of AMD-related blindness in 2020 (among those aged ≥ 50 years) was 0.10% (0.07 to 0.12) globally, and the region with the highest prevalence of AMD-related blindness was North Africa/Middle East (0.22%; 0.16 to 0.30). Age-standardized prevalence (using the GBD 2019 data) of AMD-related MSVI in people aged ≥ 50 years in 2020 was 0.34% (0.27 to 0.41) globally, and the region with the highest prevalence of AMD-related MSVI was also North Africa/Middle East (0.55%; 0.44 to 0.68). From 2000 to 2020, the estimated crude prevalence of AMD-related blindness decreased globally by 19.29%, while the prevalence of MSVI increased by 10.08%. Conclusions: The estimated increase in the number of individuals with AMD-related blindness and MSVI globally urges the creation of novel treatment modalities and the expansion of rehabilitation services.",

author = "{Vision Loss Expert Group of the Global Burden of Disease Study} and {the GBD 2019 Blindness and Vision Impairment Collaborators} and Furtado, {Jo{\~a}o M.} and Jonas, {Jost B.} and Ian Tapply and Fernandes, {Arthur G.} and Cicinelli, {Maria Vittoria} and Alessandro Arrigo and Nicolas Leveziel and Serge Resnikoff and Taylor, {Hugh R.} and Tabassom Sedighi and Seth Flaxman and {Battaglia Parodi}, Maurizio and Bikbov, {Mukkharram M.} and Tasanee Braithwaite and Alain Bron and Cheng, {Ching Yu} and Nathan Congdon and {Del Monte}, {Monte A.} and Ehrlich, {Joshua R.} and Tim Fricke and David Friedman and Gus Gazzard and Hartnett, {M. Elizabeth} and Rim Kahloun and Kempen, {John H.} and Moncef Khairallah and Khanna, {Rohit C.} and Kim, {Judy E.} and Lansingh, {Van Charles} and Leasher, {Janet L.} and Naidoo, {Kovin S.} and Vinay Nangia and Michal Nowak and Konrad Pesudovs and Tunde Peto and Pradeep Ramulu and Fotis Topouzis and Mitiadis Tsilimbaris and Wang, {Ya Xing} and Ningli Wang and Bourne, {Rupert R.A.} and Furtado, {Jo{\~a}o M.} and Jonas, {Jost B.} and Fernandes, {Arthur G.} and Cicinelli, {Maria Vittoria} and Nicolas Leveziel and Briant, {Paul Svitil} and Theo Vos and Serge Resnikoff and Florian Fischer and Abate, {Yohannes Habtegiorgis} and Mohammad Abdollahi and Adal, {Tadele Girum Girum} and Addo, {Isaac Yeboah} and Kishor Adhikari and Prerna Agarwal and Antonella Agodi and Williams Agyemang-Duah and Aqeel Ahmad and Hamid Ahmadieh and Hooman Ahmadzadeh and Fares Alahdab and Alfaar, {Ahmad Samir} and Alhassan, {Robert Kaba} and Ali, {Syed Shujait Shujait} and Louay Almidani and Sofia Androudi and Abhishek Anil and Anyasodor, {Anayochukwu Edward} and Jalal Arabloo and Ashemo, {Mubarek Yesse} and Athari, {Seyyed Shamsadin} and Atnafu, {Desta Debalkie} and Alok Atreya and Ayalew, {Melese Kitu} and Aynalem, {Yared Asmare} and Aynalem, {Zewdu Bishaw} and Azzam, {Ahmed Y.} and Sara Bagherieh and Ruhai Bai and Martina Barchitta and Mainak Bardhan and B{\"a}rnighausen, {Till Winfried} and Bayileyegn, {Nebiyou Simegnew} and Fatemeh Bazvand and Ahmet Begde and Babak Behnam and Bhagavathula, {Akshaya Srikanth} and Sonu Bhaskar and Bhatti, {Gurjit Kaur} and Bhatti, {Jasvinder Singh} and Bintoro, {Bagas Suryo} and Birck, {Marina G.} and Tasanee Braithwaite and Katrin Burkart and Yasser Bustanji and {Caetano dos Santos}, {Florentino L.} and Carneiro, {Vera L.A.} and Muthia Cenderadewi and Chattu, {Vijay Kumar} and Chu, {Dinh Toi} and Kaleb Coberly and Nat{\'a}lia Cruz-Martins and Omid Dadras and Xiaochen Dai and Dascalu, {Ana Maria} and Mohsen Dashti and Anna Dastiridou and Maedeh Dastmardi and Xinlei Deng and Nikolaos Dervenis and Devanbu, {Vinoth Gnana Chellaiyan} and Mengistie Diress and Shirin Djalalinia and Ehrlich, {Joshua R.} and Michael Ekholuenetale and Ekundayo, {Temitope Cyrus} and {El Sayed}, Iman and Muhammed Elhadi and Mehdi Emamverdi and Emrie, {Ambaw Abebaw} and Fagbamigbe, {Adeniyi Francis} and Ayesha Fahim and Umar Farooq and Hossein Farrokhpour and Ali Fatehizadeh and Alireza Feizkhah and {Ferro Desideri}, Lorenzo and Getahun Fetensa and Feyisa, {Bikila Regassa} and Seth Flaxman and Ali Forouhari and Matteo Foschi and Fowobaje, {Kayode Raphael} and Gandhi, {Aravind P.} and Gebi, {Tilaye Gebru} and Gebregergis, {Miglas W.} and Mesfin Gebrehiwot and Brhane Gebremariam and Gebremeskel, {Gebreamlak Gebremedhn} and Gela, {Yibeltal Yismaw} and Gesese, {Molalegn Mesele} and {Ghasemi Falavarjani}, Khalil and Fariba Ghassemi and Sherief Ghozy and Mahaveer Golechha and Pouya Goleij and Sapna Gupta and Gupta, {Veer Bala} and Gupta, {Vivek Kumar} and Haile, {Teklehaimanot Gereziher} and Hailu, {Semira Goitom} and Arvin Haj-Mirzaian and Aram Halimi and Shahin Hallaj and Hammond, {Billy Randall} and Ikramul Hasan and Hamidreza Hasani and Hossein Hassanian-Moghaddam and Mahsa Heidari-Foroozan and Hong, {Sung Hwi} and Praveen Hoogar and Mehdi Hosseinzadeh and Chengxi Hu and Huynh, {Hong Han} and Mustapha Immurana and Iwu, {Chidozie C.D.} and Louis Jacob and Abdollah Jafarzadeh and Mihajlo Jakovljevic and Shubha Jayaram and Mohammad Jokar and Nitin Joseph and Joshua, {Charity Ehimwenma} and Kabito, {Gebisa Guyasa} and Kalankesh, {Laleh R.} and Sagarika Kamath and Himal Kandel and Karaye, {Ibraheem M.} and Hengameh Kasraei and Kayode, {Gbenga A.} and Shemsu Kedir and Khader, {Yousef Saleh} and Himanshu Khajuria and Khatatbeh, {Moawiah Mohammad} and Khatib, {Mahalaqua Nazli} and Zahra Khorrami and Kim, {Yun Jin} and Adnan Kisa and Sezer Kisa and Soewarta Kosen and Ai Koyanagi and Kewal Krishan and Chandrakant Lahariya and Tri Laksono and Lal, {Dharmesh Kumar} and Lansingh, {Van Charles} and Le, {Trang D.T.} and Leasher, {Janet L.} and Munjae Lee and Lee, {Seung Won} and Lee, {Wei Chen} and Lim, {Stephen S.} and Xuefeng Liu and Alireza Mahmoudi and Razzagh Mahmoudi and Kashish Malhotra and Vahid Mansouri and Marzo, {Roy Rillera} and Andrea Maugeri and Colm McAlinden and {Mekene Meto}, Tesfahun and Mersha, {Abera M.} and Tomislav Mestrovic and Mihretie, {Ephrem Tesfaye} and Mehdi Mirzaei and Prasanna Mithra and Mohamed, {Nouh Saad} and Soheil Mohammadi and Abdulwase Mohammed and Mokdad, {Ali H.} and {Molavi Vardanjani}, Hossein and Moni, {Mohammad Ali} and Fateme Montazeri and Maryam Moradi and Parsa Mousavi and Muhamed, {Ahmed Nuru} and Admir Mulita and Naidoo, {Kovin S.} and Naik, {Ganesh R.} and Shumaila Nargus and Natto, {Zuhair S.} and Nayak, {Biswa Prakash} and Mohammad Negaresh and Hadush Negash and Nejadghaderi, {Seyed Aria} and Nguyen, {Dang H.} and Nguyen, {Hien Quang} and Nguyen, {Phat Tuan} and Nguyen, {Van Thanh} and Niazi, {Robina Khan} and Mamoona Noreen and Nzoputam, {Ogochukwu Janet} and Odetokun, {Ismail A.} and Olagunju, {Andrew T.} and Olatubi, {Matthew Idowu} and Onwujekwe, {Obinna E.} and Michal Ordak and Osuagwu, {Uchechukwu Levi} and Nikita Otstavnov",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = mar,

day = "9",

doi = "10.1038/s41433-024-03050-z",

language = "English",

volume = "38",

pages = "2070--2082",

journal = "Eye (Basingstoke)",

issn = "0950-222X",

publisher = "Springer Nature",

number = "11",

}

Global estimates on the number of people blind or visually impaired by age-related macular degeneration: a meta-analysis from 2000 to 2020. / Vision Loss Expert Group of the Global Burden of Disease Study; the GBD 2019 Blindness and Vision Impairment Collaborators.
In: Eye (Basingstoke), Vol. 38, No. 11, 09.03.2024, p. 2070-2082.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Global estimates on the number of people blind or visually impaired by age-related macular degeneration

T2 - a meta-analysis from 2000 to 2020

AU - Vision Loss Expert Group of the Global Burden of Disease Study

AU - the GBD 2019 Blindness and Vision Impairment Collaborators

AU - Furtado, João M.

AU - Jonas, Jost B.

AU - Tapply, Ian

AU - Fernandes, Arthur G.

AU - Cicinelli, Maria Vittoria

AU - Arrigo, Alessandro

AU - Leveziel, Nicolas

AU - Resnikoff, Serge

AU - Taylor, Hugh R.

AU - Sedighi, Tabassom

AU - Flaxman, Seth

AU - Battaglia Parodi, Maurizio

AU - Bikbov, Mukkharram M.

AU - Braithwaite, Tasanee

AU - Bron, Alain

AU - Cheng, Ching Yu

AU - Congdon, Nathan

AU - Del Monte, Monte A.

AU - Ehrlich, Joshua R.

AU - Fricke, Tim

AU - Friedman, David

AU - Gazzard, Gus

AU - Hartnett, M. Elizabeth

AU - Kahloun, Rim

AU - Kempen, John H.

AU - Khairallah, Moncef

AU - Khanna, Rohit C.

AU - Kim, Judy E.

AU - Lansingh, Van Charles

AU - Leasher, Janet L.

AU - Naidoo, Kovin S.

AU - Nangia, Vinay

AU - Nowak, Michal

AU - Pesudovs, Konrad

AU - Peto, Tunde

AU - Ramulu, Pradeep

AU - Topouzis, Fotis

AU - Tsilimbaris, Mitiadis

AU - Wang, Ya Xing

AU - Wang, Ningli

AU - Bourne, Rupert R.A.

AU - Furtado, João M.

AU - Jonas, Jost B.

AU - Fernandes, Arthur G.

AU - Cicinelli, Maria Vittoria

AU - Leveziel, Nicolas

AU - Briant, Paul Svitil

AU - Vos, Theo

AU - Resnikoff, Serge

AU - Fischer, Florian

AU - Abate, Yohannes Habtegiorgis

AU - Abdollahi, Mohammad

AU - Adal, Tadele Girum Girum

AU - Addo, Isaac Yeboah

AU - Adhikari, Kishor

AU - Agarwal, Prerna

AU - Agodi, Antonella

AU - Agyemang-Duah, Williams

AU - Ahmad, Aqeel

AU - Ahmadieh, Hamid

AU - Ahmadzadeh, Hooman

AU - Alahdab, Fares

AU - Alfaar, Ahmad Samir

AU - Alhassan, Robert Kaba

AU - Ali, Syed Shujait Shujait

AU - Almidani, Louay

AU - Androudi, Sofia

AU - Anil, Abhishek

AU - Anyasodor, Anayochukwu Edward

AU - Arabloo, Jalal

AU - Ashemo, Mubarek Yesse

AU - Athari, Seyyed Shamsadin

AU - Atnafu, Desta Debalkie

AU - Atreya, Alok

AU - Ayalew, Melese Kitu

AU - Aynalem, Yared Asmare

AU - Aynalem, Zewdu Bishaw

AU - Azzam, Ahmed Y.

AU - Bagherieh, Sara

AU - Bai, Ruhai

AU - Barchitta, Martina

AU - Bardhan, Mainak

AU - Bärnighausen, Till Winfried

AU - Bayileyegn, Nebiyou Simegnew

AU - Bazvand, Fatemeh

AU - Begde, Ahmet

AU - Behnam, Babak

AU - Bhagavathula, Akshaya Srikanth

AU - Bhaskar, Sonu

AU - Bhatti, Gurjit Kaur

AU - Bhatti, Jasvinder Singh

AU - Bintoro, Bagas Suryo

AU - Birck, Marina G.

AU - Braithwaite, Tasanee

AU - Burkart, Katrin

AU - Bustanji, Yasser

AU - Caetano dos Santos, Florentino L.

AU - Carneiro, Vera L.A.

AU - Cenderadewi, Muthia

AU - Chattu, Vijay Kumar

AU - Chu, Dinh Toi

AU - Coberly, Kaleb

AU - Cruz-Martins, Natália

AU - Dadras, Omid

AU - Dai, Xiaochen

AU - Dascalu, Ana Maria

AU - Dashti, Mohsen

AU - Dastiridou, Anna

AU - Dastmardi, Maedeh

AU - Deng, Xinlei

AU - Dervenis, Nikolaos

AU - Devanbu, Vinoth Gnana Chellaiyan

AU - Diress, Mengistie

AU - Djalalinia, Shirin

AU - Ehrlich, Joshua R.

AU - Ekholuenetale, Michael

AU - Ekundayo, Temitope Cyrus

AU - El Sayed, Iman

AU - Elhadi, Muhammed

AU - Emamverdi, Mehdi

AU - Emrie, Ambaw Abebaw

AU - Fagbamigbe, Adeniyi Francis

AU - Fahim, Ayesha

AU - Farooq, Umar

AU - Farrokhpour, Hossein

AU - Fatehizadeh, Ali

AU - Feizkhah, Alireza

AU - Ferro Desideri, Lorenzo

AU - Fetensa, Getahun

AU - Feyisa, Bikila Regassa

AU - Flaxman, Seth

AU - Forouhari, Ali

AU - Foschi, Matteo

AU - Fowobaje, Kayode Raphael

AU - Gandhi, Aravind P.

AU - Gebi, Tilaye Gebru

AU - Gebregergis, Miglas W.

AU - Gebrehiwot, Mesfin

AU - Gebremariam, Brhane

AU - Gebremeskel, Gebreamlak Gebremedhn

AU - Gela, Yibeltal Yismaw

AU - Gesese, Molalegn Mesele

AU - Ghasemi Falavarjani, Khalil

AU - Ghassemi, Fariba

AU - Ghozy, Sherief

AU - Golechha, Mahaveer

AU - Goleij, Pouya

AU - Gupta, Sapna

AU - Gupta, Veer Bala

AU - Gupta, Vivek Kumar

AU - Haile, Teklehaimanot Gereziher

AU - Hailu, Semira Goitom

AU - Haj-Mirzaian, Arvin

AU - Halimi, Aram

AU - Hallaj, Shahin

AU - Hammond, Billy Randall

AU - Hasan, Ikramul

AU - Hasani, Hamidreza

AU - Hassanian-Moghaddam, Hossein

AU - Heidari-Foroozan, Mahsa

AU - Hong, Sung Hwi

AU - Hoogar, Praveen

AU - Hosseinzadeh, Mehdi

AU - Hu, Chengxi

AU - Huynh, Hong Han

AU - Immurana, Mustapha

AU - Iwu, Chidozie C.D.

AU - Jacob, Louis

AU - Jafarzadeh, Abdollah

AU - Jakovljevic, Mihajlo

AU - Jayaram, Shubha

AU - Jokar, Mohammad

AU - Joseph, Nitin

AU - Joshua, Charity Ehimwenma

AU - Kabito, Gebisa Guyasa

AU - Kalankesh, Laleh R.

AU - Kamath, Sagarika

AU - Kandel, Himal

AU - Karaye, Ibraheem M.

AU - Kasraei, Hengameh

AU - Kayode, Gbenga A.

AU - Kedir, Shemsu

AU - Khader, Yousef Saleh

AU - Khajuria, Himanshu

AU - Khatatbeh, Moawiah Mohammad

AU - Khatib, Mahalaqua Nazli

AU - Khorrami, Zahra

AU - Kim, Yun Jin

AU - Kisa, Adnan

AU - Kisa, Sezer

AU - Kosen, Soewarta

AU - Koyanagi, Ai

AU - Krishan, Kewal

AU - Lahariya, Chandrakant

AU - Laksono, Tri

AU - Lal, Dharmesh Kumar

AU - Lansingh, Van Charles

AU - Le, Trang D.T.

AU - Leasher, Janet L.

AU - Lee, Munjae

AU - Lee, Seung Won

AU - Lee, Wei Chen

AU - Lim, Stephen S.

AU - Liu, Xuefeng

AU - Mahmoudi, Alireza

AU - Mahmoudi, Razzagh

AU - Malhotra, Kashish

AU - Mansouri, Vahid

AU - Marzo, Roy Rillera

AU - Maugeri, Andrea

AU - McAlinden, Colm

AU - Mekene Meto, Tesfahun

AU - Mersha, Abera M.

AU - Mestrovic, Tomislav

AU - Mihretie, Ephrem Tesfaye

AU - Mirzaei, Mehdi

AU - Mithra, Prasanna

AU - Mohamed, Nouh Saad

AU - Mohammadi, Soheil

AU - Mohammed, Abdulwase

AU - Mokdad, Ali H.

AU - Molavi Vardanjani, Hossein

AU - Moni, Mohammad Ali

AU - Montazeri, Fateme

AU - Moradi, Maryam

AU - Mousavi, Parsa

AU - Muhamed, Ahmed Nuru

AU - Mulita, Admir

AU - Naidoo, Kovin S.

AU - Naik, Ganesh R.

AU - Nargus, Shumaila

AU - Natto, Zuhair S.

AU - Nayak, Biswa Prakash

AU - Negaresh, Mohammad

AU - Negash, Hadush

AU - Nejadghaderi, Seyed Aria

AU - Nguyen, Dang H.

AU - Nguyen, Hien Quang

AU - Nguyen, Phat Tuan

AU - Nguyen, Van Thanh

AU - Niazi, Robina Khan

AU - Noreen, Mamoona

AU - Nzoputam, Ogochukwu Janet

AU - Odetokun, Ismail A.

AU - Olagunju, Andrew T.

AU - Olatubi, Matthew Idowu

AU - Onwujekwe, Obinna E.

AU - Ordak, Michal

AU - Osuagwu, Uchechukwu Levi

AU - Otstavnov, Nikita

PY - 2024/3/9

Y1 - 2024/3/9

N2 - Background: We aimed to update estimates of global vision loss due to age-related macular degeneration (AMD). Methods: We did a systematic review and meta-analysis of population-based surveys of eye diseases from January, 1980, to October, 2018. We fitted hierarchical models to estimate the prevalence of moderate and severe vision impairment (MSVI; presenting visual acuity from <6/18 to 3/60) and blindness (< 3/60) caused by AMD, stratified by age, region, and year. Results: In 2020, 1.85 million (95%UI: 1.35 to 2.43 million) people were estimated to be blind due to AMD, and another 6.23 million (95%UI: 5.04 to 7.58) with MSVI globally. High-income countries had the highest number of individuals with AMD-related blindness (0.60 million people; 0.46 to 0.77). The crude prevalence of AMD-related blindness in 2020 (among those aged ≥ 50 years) was 0.10% (0.07 to 0.12) globally, and the region with the highest prevalence of AMD-related blindness was North Africa/Middle East (0.22%; 0.16 to 0.30). Age-standardized prevalence (using the GBD 2019 data) of AMD-related MSVI in people aged ≥ 50 years in 2020 was 0.34% (0.27 to 0.41) globally, and the region with the highest prevalence of AMD-related MSVI was also North Africa/Middle East (0.55%; 0.44 to 0.68). From 2000 to 2020, the estimated crude prevalence of AMD-related blindness decreased globally by 19.29%, while the prevalence of MSVI increased by 10.08%. Conclusions: The estimated increase in the number of individuals with AMD-related blindness and MSVI globally urges the creation of novel treatment modalities and the expansion of rehabilitation services.

AB - Background: We aimed to update estimates of global vision loss due to age-related macular degeneration (AMD). Methods: We did a systematic review and meta-analysis of population-based surveys of eye diseases from January, 1980, to October, 2018. We fitted hierarchical models to estimate the prevalence of moderate and severe vision impairment (MSVI; presenting visual acuity from <6/18 to 3/60) and blindness (< 3/60) caused by AMD, stratified by age, region, and year. Results: In 2020, 1.85 million (95%UI: 1.35 to 2.43 million) people were estimated to be blind due to AMD, and another 6.23 million (95%UI: 5.04 to 7.58) with MSVI globally. High-income countries had the highest number of individuals with AMD-related blindness (0.60 million people; 0.46 to 0.77). The crude prevalence of AMD-related blindness in 2020 (among those aged ≥ 50 years) was 0.10% (0.07 to 0.12) globally, and the region with the highest prevalence of AMD-related blindness was North Africa/Middle East (0.22%; 0.16 to 0.30). Age-standardized prevalence (using the GBD 2019 data) of AMD-related MSVI in people aged ≥ 50 years in 2020 was 0.34% (0.27 to 0.41) globally, and the region with the highest prevalence of AMD-related MSVI was also North Africa/Middle East (0.55%; 0.44 to 0.68). From 2000 to 2020, the estimated crude prevalence of AMD-related blindness decreased globally by 19.29%, while the prevalence of MSVI increased by 10.08%. Conclusions: The estimated increase in the number of individuals with AMD-related blindness and MSVI globally urges the creation of novel treatment modalities and the expansion of rehabilitation services.

UR - http://www.scopus.com/inward/record.url?scp=85199813397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85199813397&partnerID=8YFLogxK

U2 - 10.1038/s41433-024-03050-z

DO - 10.1038/s41433-024-03050-z

M3 - Article

C2 - 38965321

AN - SCOPUS:85199813397

SN - 0950-222X

VL - 38

SP - 2070

EP - 2082

JO - Eye (Basingstoke)

JF - Eye (Basingstoke)

IS - 11

ER -

Global estimates on the number of people blind or visually impaired by age-related macular degeneration: a meta-analysis from 2000 to 2020

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