Gold nanoparticles: the importance of physiological principles to devise strategies for targeted drug delivery

Madhusudhan R Papasani, Guankui Wang, RA Hill

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Nanotechnology and its promise for clinical translation to targeted drug delivery with limited accompanying toxicity provide exciting research opportunities that demand multidisciplinary approaches. To make rapid progress in the design of nano-platforms for drug delivery and toward their use in the clinic, basic and mechanistic studies must first be tested in vitro and then progress to in vivo studies in animal models, incorporating an understanding of body functioning. Recently, gold nanoparticles (Au NPs) have gained much attention as model drug delivery platforms because of their advantageous surface characteristics that allow easy functionalization with chemical and biological molecules and also due to their apparently low toxicity. In this study we review recent in vitro and in vivo research progress with Au NPs as drug delivery platforms and suggest experimental strategies for future studies for efficacious, targeted delivery.|From the Clinical Editor: The role and significance of gold nanoparticles is discussed in this comprehensive review. Au NP-s are expected to become a clinically utilized drug delivery platform enabling easy functionalization and overall low toxicity. (C) 2012 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)804-814
Number of pages11
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume8
Issue number6
Early online dateJan 2012
DOIs
Publication statusPublished - Aug 2012

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Drug delivery
Gold
Nanoparticles
Toxicity
Pharmaceutical Preparations
Nanotechnology
Animals
Research
Animal Models
Molecules
Targeted drug delivery
In Vitro Techniques

Cite this

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Gold nanoparticles: the importance of physiological principles to devise strategies for targeted drug delivery. / Papasani, Madhusudhan R; Wang, Guankui; Hill, RA.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 8, No. 6, 08.2012, p. 804-814.

Research output: Contribution to journalArticle

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