Gut Microbiome-Induced Shift of Acetate to Butyrate Positively Manages Dysbiosis in High Fat Diet

Xu Si, Wenting Shang, Zhongkai Zhou, Padraig Strappe, Bing Wang, Anthony Bird, Chris Blanchard

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A recent study revealed that the accumulation of gut microbiota-produced acetate (GMPA) led to insulin over-secretion and obesity symptom. To further develop this scientific point, the effect of resistant starch (RS) or exogenous acetate carried by RS (RSA) in the gut on metabolic syndrome is investigated using diet-induced obese rats. Methods and results: The metabonomics analysis shows that the gut of rats in the RSA group generate more butyrate in both serum and feces rather than acetate compared to the rats in RS group, indicating the conversion among metabolites, in particular from acetate to butyrate via gut microbiota. Consistently, the gut microbiome uses acetate as a substrate to produce butyrate, such as Coprococcus, Faecalibacterium, Roseburia, and Eubacterium and was highly promoted in RSA group, which further supports the metabolic conversion. This is the first report to reveal the accumulation of gut microbiota-produced butyrate (GMPB) but not GMPA significantly enriched AMPK signaling pathway with reduced expression of lipogenesis-associated genes for suppressing sphingosines and ceramides biosynthesis to trigger insulin sensitivity. Conclusion: Gut microbiome profile and lipogenesis pathway are regulated by GMPB, which substantially influences energy harvesting in the gut from patterns opposed to GMPA.
Original languageEnglish
Article number1700670
Pages (from-to)1-12
Number of pages12
JournalMolecular Nutrition and Food Research
Volume62
Issue number3
Early online dateNov 2017
DOIs
Publication statusPublished - Feb 2018

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Dysbiosis
Butyrates
High Fat Diet
high fat diet
butyrates
intestinal microorganisms
Acetates
digestive system
acetates
resistant starch
lipogenesis
Starch
Coprococcus
Lipogenesis
Roseburia
rats
lead acetate
sphingosine
Eubacteria
ceramides

Cite this

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title = "Gut Microbiome-Induced Shift of Acetate to Butyrate Positively Manages Dysbiosis in High Fat Diet",
abstract = "A recent study revealed that the accumulation of gut microbiota-produced acetate (GMPA) led to insulin over-secretion and obesity symptom. To further develop this scientific point, the effect of resistant starch (RS) or exogenous acetate carried by RS (RSA) in the gut on metabolic syndrome is investigated using diet-induced obese rats. Methods and results: The metabonomics analysis shows that the gut of rats in the RSA group generate more butyrate in both serum and feces rather than acetate compared to the rats in RS group, indicating the conversion among metabolites, in particular from acetate to butyrate via gut microbiota. Consistently, the gut microbiome uses acetate as a substrate to produce butyrate, such as Coprococcus, Faecalibacterium, Roseburia, and Eubacterium and was highly promoted in RSA group, which further supports the metabolic conversion. This is the first report to reveal the accumulation of gut microbiota-produced butyrate (GMPB) but not GMPA significantly enriched AMPK signaling pathway with reduced expression of lipogenesis-associated genes for suppressing sphingosines and ceramides biosynthesis to trigger insulin sensitivity. Conclusion: Gut microbiome profile and lipogenesis pathway are regulated by GMPB, which substantially influences energy harvesting in the gut from patterns opposed to GMPA.",
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Gut Microbiome-Induced Shift of Acetate to Butyrate Positively Manages Dysbiosis in High Fat Diet. / Si, Xu; Shang, Wenting; Zhou, Zhongkai; Strappe, Padraig; Wang, Bing; Bird, Anthony; Blanchard, Chris.

In: Molecular Nutrition and Food Research, Vol. 62, No. 3, 1700670, 02.2018, p. 1-12.

Research output: Contribution to journalArticle

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AU - Wang, Bing

AU - Bird, Anthony

AU - Blanchard, Chris

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