Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals

Simona D. Frederiksen, Peter Karlskov-Mortensen, Sameer D. Pant, Maryse Guerin, Philippe Lesnik, Claus B. Jørgensen, Susanna Cirera, Camilla S. Bruun, Thomas Mark, Merete Fredholm

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Abstract

We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Gottingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3). Large additive genetic effects were found for the HDL-C/CT and LDL-C haplotypes. Haplotypes segregating from Gottingen Minipigs were shown to impose a positive effect on blood lipid levels. Thus, the genetic profile of the Gottingen Minipig breed seems to support a phenotype comparable to the metabolic healthy obese (MHO) phenotype in humans.

Original languageEnglish
Article numbere0178828
Pages (from-to)1-13
Number of pages13
JournalPLoS One
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 2017

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    Frederiksen, S. D., Karlskov-Mortensen, P., Pant, S. D., Guerin, M., Lesnik, P., Jørgensen, C. B., Cirera, S., Bruun, C. S., Mark, T., & Fredholm, M. (2017). Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals. PLoS One, 12(6), 1-13. [e0178828]. https://doi.org/10.1371/journal.pone.0178828