Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study)

Laboratory Medicine Department, Hospital Universitario Santa Lucía, Luis García de Guadiana-Romualdo, Daniel Morell-García, Emmanuel J Favaloro, Juan A Vílchez, Josep M Bauça, María J Alcaide Martín, Irene Gutiérrez Garcia, Patricia de la Hera Cagigal, José Manuel Egea-Caparrós, Sonia Pérez Sanmartín, José I Gutiérrez Revilla, Eloísa Urrechaga, Jose M Álamo, Ana M Hernando Holgado, María-Carmen Lorenzo-Lozano, Magdalena Canalda Campás, María A Juncos Tobarra, Cristian Morales-Indiano, Isabel Vírseda ChamorroYolanda Pastor Murcia, Laura Sahuquillo Frías, Laura Altimira Queral, Elisa Nuez-Zaragoza, Juan Adell Ruiz de León, Alicia Ruiz Ripa, Paloma Salas Gómez-Pablos, Iria Cebreiros López, Amaia Fernández Uriarte, Alex Larruzea, María L López Yepes, Natalia Sancho-Rodríguez, María C Zamorano Andrés, José Pedregosa Díaz, Luis Sáenz, Clara Esparza Del Valle, María C Baamonde Calzada, Sara García Muñoz, Marina Vera, Esther Martín Torres, Silvia Sánchez Fdez-Pacheco, Luis Vicente Gutiérrez, Laura Jiménez Añón, Alfonso Pérez Martínez, Aurelio Pons Castillo, Ruth González Tamayo, Jorge Férriz Vivancos, Olaia Rodríguez-Fraga, Vicens Díaz-Brito, Vicente Aguadero, M G García Arévalo, María Arnaldos Carrillo, Mercedes González Morales, María Núñez Gárate, Cristina Ruiz Iruela, Patricia Esteban Torrella, Martí Vila Pérez, Cristina Acevedo Alcaraz, Alfonso L Blázquez-Manzanera, Amparo Galán Ortega

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Coagulopathy is a key feature of COVID-19 and D-dimer has been reported as a predictor of severity. However, because D-dimer test results vary considerably among assays, resolving harmonization issues is fundamental to translate findings into clinical practice. In this retrospective multicenter study (BIOCOVID study), we aimed to analyze the value of harmonized D-dimer levels upon admission for the prediction of in-hospital mortality in COVID-19 patients. All-cause in-hospital mortality was defined as endpoint. For harmonization of D-dimer levels, we designed a model based on the transformation of method-specific regression lines to a reference regression line. The ability of D-dimer for prediction of death was explored by receiver operating characteristic curves analysis and the association with the endpoint by Cox regression analysis. Study population included 2663 patients. In-hospital mortality rate was 14.3%. Harmonized D-dimer upon admission yielded an area under the curve of 0.66, with an optimal cut-off value of 0.945 mg/L FEU. Patients with harmonized D-dimer ≥ 0.945 mg/L FEU had a higher mortality rate (22.4% vs. 9.2%; p 
Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalJournal of Thrombosis and Thrombolysis
Volume53
Issue number1
DOIs
Publication statusPublished - Jan 2022

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