TY - JOUR
T1 - Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity
T2 - Results from a Spanish multicenter registry (BIOCOVID-Spain study)
AU - Laboratory Medicine Department, Hospital Universitario Santa Lucía
AU - García de Guadiana-Romualdo, Luis
AU - Morell-García, Daniel
AU - Favaloro, Emmanuel J
AU - Vílchez, Juan A
AU - Bauça, Josep M
AU - Alcaide Martín, María J
AU - Gutiérrez Garcia, Irene
AU - de la Hera Cagigal, Patricia
AU - Egea-Caparrós, José Manuel
AU - Pérez Sanmartín, Sonia
AU - Gutiérrez Revilla, José I
AU - Urrechaga, Eloísa
AU - Álamo, Jose M
AU - Hernando Holgado, Ana M
AU - Lorenzo-Lozano, María-Carmen
AU - Canalda Campás, Magdalena
AU - Juncos Tobarra, María A
AU - Morales-Indiano, Cristian
AU - Vírseda Chamorro, Isabel
AU - Pastor Murcia, Yolanda
AU - Sahuquillo Frías, Laura
AU - Altimira Queral, Laura
AU - Nuez-Zaragoza, Elisa
AU - Adell Ruiz de León, Juan
AU - Ruiz Ripa, Alicia
AU - Salas Gómez-Pablos, Paloma
AU - Cebreiros López, Iria
AU - Fernández Uriarte, Amaia
AU - Larruzea, Alex
AU - López Yepes, María L
AU - Sancho-Rodríguez, Natalia
AU - Zamorano Andrés, María C
AU - Pedregosa Díaz, José
AU - Sáenz, Luis
AU - Esparza Del Valle, Clara
AU - Baamonde Calzada, María C
AU - García Muñoz, Sara
AU - Vera, Marina
AU - Martín Torres, Esther
AU - Sánchez Fdez-Pacheco, Silvia
AU - Vicente Gutiérrez, Luis
AU - Jiménez Añón, Laura
AU - Pérez Martínez, Alfonso
AU - Pons Castillo, Aurelio
AU - González Tamayo, Ruth
AU - Férriz Vivancos, Jorge
AU - Rodríguez-Fraga, Olaia
AU - Díaz-Brito, Vicens
AU - Aguadero, Vicente
AU - García Arévalo, M G
AU - Arnaldos Carrillo, María
AU - González Morales, Mercedes
AU - Núñez Gárate, María
AU - Ruiz Iruela, Cristina
AU - Esteban Torrella, Patricia
AU - Vila Pérez, Martí
AU - Acevedo Alcaraz, Cristina
AU - Blázquez-Manzanera, Alfonso L
AU - Galán Ortega, Amparo
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/1
Y1 - 2022/1
N2 - Coagulopathy is a key feature of COVID-19 and D-dimer has been reported as a predictor of severity. However, because D-dimer test results vary considerably among assays, resolving harmonization issues is fundamental to translate findings into clinical practice. In this retrospective multicenter study (BIOCOVID study), we aimed to analyze the value of harmonized D-dimer levels upon admission for the prediction of in-hospital mortality in COVID-19 patients. All-cause in-hospital mortality was defined as endpoint. For harmonization of D-dimer levels, we designed a model based on the transformation of method-specific regression lines to a reference regression line. The ability of D-dimer for prediction of death was explored by receiver operating characteristic curves analysis and the association with the endpoint by Cox regression analysis. Study population included 2663 patients. In-hospital mortality rate was 14.3%. Harmonized D-dimer upon admission yielded an area under the curve of 0.66, with an optimal cut-off value of 0.945 mg/L FEU. Patients with harmonized D-dimer ≥ 0.945 mg/L FEU had a higher mortality rate (22.4% vs. 9.2%; p
AB - Coagulopathy is a key feature of COVID-19 and D-dimer has been reported as a predictor of severity. However, because D-dimer test results vary considerably among assays, resolving harmonization issues is fundamental to translate findings into clinical practice. In this retrospective multicenter study (BIOCOVID study), we aimed to analyze the value of harmonized D-dimer levels upon admission for the prediction of in-hospital mortality in COVID-19 patients. All-cause in-hospital mortality was defined as endpoint. For harmonization of D-dimer levels, we designed a model based on the transformation of method-specific regression lines to a reference regression line. The ability of D-dimer for prediction of death was explored by receiver operating characteristic curves analysis and the association with the endpoint by Cox regression analysis. Study population included 2663 patients. In-hospital mortality rate was 14.3%. Harmonized D-dimer upon admission yielded an area under the curve of 0.66, with an optimal cut-off value of 0.945 mg/L FEU. Patients with harmonized D-dimer ≥ 0.945 mg/L FEU had a higher mortality rate (22.4% vs. 9.2%; p
KW - Biomarkers/blood
KW - COVID-19/diagnosis
KW - Fibrin Fibrinogen Degradation Products/analysis
KW - Humans
KW - Prognosis
KW - Registries
KW - Retrospective Studies
KW - Severity of Illness Index
KW - Spain/epidemiology
KW - Mortality
KW - D-dimer
KW - Harmonization
KW - COVID-19
UR - http://www.scopus.com/inward/record.url?scp=85110409626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85110409626&partnerID=8YFLogxK
U2 - 10.1007/s11239-021-02527-y
DO - 10.1007/s11239-021-02527-y
M3 - Article
C2 - 34272635
SN - 0929-5305
VL - 53
SP - 103
EP - 112
JO - Journal of Thrombosis and Thrombolysis
JF - Journal of Thrombosis and Thrombolysis
IS - 1
ER -