TY - JOUR
T1 - Helminths, polyparasitism, and the gut microbiome in the Philippines
AU - Gordon, Catherine A.
AU - Krause, Lutz
AU - McManus, Donald P.
AU - Morrison, Mark
AU - Weerakoon, Kosala G.
AU - Connor, Mairead C.
AU - Olveda, Remigio M.
AU - Ross, Allen G.
AU - Gobert, Geoffrey N.
N1 - Funding Information:
We would like to acknowledge the excellent work of Tal Bavli (QIMRB, Australia) for designing Fig. 1 . The authors would like to acknowledge funding from UBS Optimus Foundation, Switzerland and the Australian National Health and Medical Research Council for the cohort sample collection in the Philippines and the Australian Infectious Diseases (AID) Research Centre for seed funding for the microbiome 16S RNA analysis at the Australian Genome Research Facility (AGRF).
Publisher Copyright:
© 2020 Australian Society for Parasitology
PY - 2020/3
Y1 - 2020/3
N2 - Polyparasitism, involving soil-transmitted helminths. and Schistosoma blood flukes, is common in low to middle income countries. These helminths impact on the gut environment and can cause changes to the gut microbiome composition. Here we examined the gut microbiome in individuals with polyparasitism from two human cohorts in the Philippines utilising DNA sequencing-based profiling. Multiple helminth species infections were high with 70.3% of study participants harbouring at least two parasite species, and 16% harbouring at least five species. Increased numbers of helminth co-infections, in particular with the gut-resident soil-transmitted helminths, were significantly associated with increased bacterial diversity; however no significant parasite-gut microbiome associations were evident for individuals infected only with Schistosoma japonicum. In general, a healthy gut is associated with high bacterial diversity, which in these human cohorts may be the result of helminth-mediated immune modulation, or due to changes in the gut environment caused by these parasitic helminths.
AB - Polyparasitism, involving soil-transmitted helminths. and Schistosoma blood flukes, is common in low to middle income countries. These helminths impact on the gut environment and can cause changes to the gut microbiome composition. Here we examined the gut microbiome in individuals with polyparasitism from two human cohorts in the Philippines utilising DNA sequencing-based profiling. Multiple helminth species infections were high with 70.3% of study participants harbouring at least two parasite species, and 16% harbouring at least five species. Increased numbers of helminth co-infections, in particular with the gut-resident soil-transmitted helminths, were significantly associated with increased bacterial diversity; however no significant parasite-gut microbiome associations were evident for individuals infected only with Schistosoma japonicum. In general, a healthy gut is associated with high bacterial diversity, which in these human cohorts may be the result of helminth-mediated immune modulation, or due to changes in the gut environment caused by these parasitic helminths.
KW - Ancylostoma
KW - Ascaris
KW - Gut microbiome
KW - Hookworm
KW - Schistosoma
KW - Soil-transmitted helminths
KW - The Philippines
KW - Trichuris
UR - http://www.scopus.com/inward/record.url?scp=85081216715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85081216715&partnerID=8YFLogxK
U2 - 10.1016/j.ijpara.2019.12.008
DO - 10.1016/j.ijpara.2019.12.008
M3 - Article
C2 - 32135180
AN - SCOPUS:85081216715
SN - 0020-7519
VL - 50
SP - 217
EP - 225
JO - International Journal for Parasitology
JF - International Journal for Parasitology
IS - 3
ER -
