Histomorphometric analysis of zirconia implants in the jaw of sheep

Allauddin Siddiqi, Warwick Duncan, Rohana De Silva, Sobia Zafar

Research output: Other contribution to conferenceAbstractpeer-review


Reports have documented titanium (Ti) hypersensitivity after dental implant treatment. Alternative materials have been suggested including zirconia (Zr) ceramic, which has shown predictable osseointegration in animal studies and appears free of immune responses.
The aim of the research was to investigate the bone implant contact (BIC) of one-piece Zr, compared with one-piece Ti implants placed in the jaws of domestic sheep.
Methods: Ten New Zealand mixed-breed sheep were used. Titanium (control n=10) and Zirconia (test n=10) one-piece prototype implants were placed using one-stage trans-gingival protocol into the post-extraction edentulous posterior mandible of each sheep. After a healing period of 12-weeks, resin-embedded undecalcified sections were prepared. Bone-to-implant contact was measured on two sections per implant using image analysis software.
Results: Gross histological evaluation of the Ti mandibular implants showed 7/10 implants were integrated, while the other three were failing. On the other hand, 3/10 Zr implants had failed and been lost, 2/10 were not integrated, one was failing and only 4/10 could be considered successfully integrated. No statistical significant difference was found (p=0.18). Overall bone-implant integration was 11/20 = 55%. Zirconia implants in the mandible showed comparable %BIC to titanium implants (72.2%, SD 23.7 versus 60.3%, SD 22.4) (p =0.087).
Conclusions: The high failure rate in the mandible could be attributed to the implant design (one-piece), the structural morphology of the sheep mandible and unfavourable forces of mastication. The outcomes of this research supported the results of other studies that have demonstrated higher failure rates of one-piece zirconia implants in clinical conditions. Further clinical trials are recommended to evaluate the performance of zirconia implants under loading conditions.
Original languageEnglish
Publication statusPublished - 2015
Event2015 IADR/AADR/CADR 93rd General Session - Boston, United States
Duration: 11 Mar 201514 Mar 2015
https://www.iadr.org/events (Access to past abstracts)


Conference2015 IADR/AADR/CADR 93rd General Session
Country/TerritoryUnited States
Internet address


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