Histopathologic indicators of breast cancer biology: insights from population mammographic screening

Lucy Webster, AM. Bilous, L. Willis, K. Byth, FC. Burgemeister, ELC. Salisbury, CL. Clarke, RL. Balleine

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Histopathologic features of breast cancer such as tumour size, grade and axillary lymph node (LN) status variably reflect tumour biology and time. Recent evidence suggests that the biological character of breast cancer is established at an early stage and has a major impact on clinical course. The aim of this study was to distinguish the impact of biology on breast cancer histopathology by comparing features of breast cancers diagnosed following population mammographic screening with prevalent vs incident detection and screening interval. Central histopathology review data from 1147 cases of ductal in situ and/or invasive breast cancer were examined. Size, grade and LN status of invasive cancers were positively correlated (P<0.001). Prevalent invasive cancers were larger (P<0.001) and more likely to be LN positive (P=0.02) than incident cases, but grade was not associated with screening episode (P=0.7). Screening interval for incident cancers was positively associated with invasive cancer size (P=0.05) and LN status (P=0.002) but not grade (P=0.1). Together, these data indicate that biology and time both impact on size and LN status of invasive breast cancer, but grade reflects biology alone. In view of the clinical importance of breast cancer biology, grade as its most direct indicator assumes particular significance.
Original languageEnglish
Pages (from-to)1366-1371
Number of pages6
JournalBritish Journal of Cancer
Volume92
Issue number8
DOIs
Publication statusPublished - 2005

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Breast Neoplasms
Lymph Nodes
Population
Neoplasms

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Webster, L., Bilous, AM., Willis, L., Byth, K., Burgemeister, FC., Salisbury, ELC., ... Balleine, RL. (2005). Histopathologic indicators of breast cancer biology: insights from population mammographic screening. British Journal of Cancer, 92(8), 1366-1371. https://doi.org/10.1038/sj.bjc.6602501
Webster, Lucy ; Bilous, AM. ; Willis, L. ; Byth, K. ; Burgemeister, FC. ; Salisbury, ELC. ; Clarke, CL. ; Balleine, RL. / Histopathologic indicators of breast cancer biology : insights from population mammographic screening. In: British Journal of Cancer. 2005 ; Vol. 92, No. 8. pp. 1366-1371.
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Webster, L, Bilous, AM, Willis, L, Byth, K, Burgemeister, FC, Salisbury, ELC, Clarke, CL & Balleine, RL 2005, 'Histopathologic indicators of breast cancer biology: insights from population mammographic screening', British Journal of Cancer, vol. 92, no. 8, pp. 1366-1371. https://doi.org/10.1038/sj.bjc.6602501

Histopathologic indicators of breast cancer biology : insights from population mammographic screening. / Webster, Lucy; Bilous, AM.; Willis, L.; Byth, K.; Burgemeister, FC.; Salisbury, ELC.; Clarke, CL.; Balleine, RL.

In: British Journal of Cancer, Vol. 92, No. 8, 2005, p. 1366-1371.

Research output: Contribution to journalArticle

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AU - Webster, Lucy

AU - Bilous, AM.

AU - Willis, L.

AU - Byth, K.

AU - Burgemeister, FC.

AU - Salisbury, ELC.

AU - Clarke, CL.

AU - Balleine, RL.

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AB - Histopathologic features of breast cancer such as tumour size, grade and axillary lymph node (LN) status variably reflect tumour biology and time. Recent evidence suggests that the biological character of breast cancer is established at an early stage and has a major impact on clinical course. The aim of this study was to distinguish the impact of biology on breast cancer histopathology by comparing features of breast cancers diagnosed following population mammographic screening with prevalent vs incident detection and screening interval. Central histopathology review data from 1147 cases of ductal in situ and/or invasive breast cancer were examined. Size, grade and LN status of invasive cancers were positively correlated (P<0.001). Prevalent invasive cancers were larger (P<0.001) and more likely to be LN positive (P=0.02) than incident cases, but grade was not associated with screening episode (P=0.7). Screening interval for incident cancers was positively associated with invasive cancer size (P=0.05) and LN status (P=0.002) but not grade (P=0.1). Together, these data indicate that biology and time both impact on size and LN status of invasive breast cancer, but grade reflects biology alone. In view of the clinical importance of breast cancer biology, grade as its most direct indicator assumes particular significance.

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