TY - JOUR
T1 - HLA Class II antigens are associated with resistance or susceptibility to hepatosplenic disease in a Chinese population infected with Schistosoma japonicum
AU - Waine, G. J.
AU - Ross, A. G.P.
AU - Williams, G. M.
AU - Sleigh, A. C.
AU - McManus, D. P.
N1 - Funding Information:
Acknowledgements-Our studies receive financial support from the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, the National Health and Medical Research Council of Australia, and CRC for Vaccine Technology. We thank Dr Yixin Huang, Jiangsu Institute of Parasitic Diseases. Jiangsu, P.R. China for selecting the patients and collecting the venous blood used in this study. We thank also Rhonda Holdsworth and Sue Bowman, Australian Red Cross Blood Bank. for carrying out the HLA typing.
PY - 1998/4
Y1 - 1998/4
N2 - The major histocompatibility Class II alleles of 108 individuals living in an area endemic for schistosomiasis japonica in China were determined to identify possible immunogenetic associations with advanced schistosomiasis. Two alleles, HLA-DRB1*1202 (P=0.002) and HLA-DQA1*0601 (P=0.001) were strongly associated with resistance to advanced disease. In contrast, HLA- DQB1*05031 (P=0.02) was associated with susceptibility to advanced schistosomiasis. The remaining alleles showed no association with advanced disease. Allele DRB1*1202 co-occurred with allele DQA1*0601; therefore, their independent protective effects could not be ascertained. In contrast, alleles DQA1*0601 and DQB1*05031 never co-occurred and had opposite and significant effects on the occurrence of disease.
AB - The major histocompatibility Class II alleles of 108 individuals living in an area endemic for schistosomiasis japonica in China were determined to identify possible immunogenetic associations with advanced schistosomiasis. Two alleles, HLA-DRB1*1202 (P=0.002) and HLA-DQA1*0601 (P=0.001) were strongly associated with resistance to advanced disease. In contrast, HLA- DQB1*05031 (P=0.02) was associated with susceptibility to advanced schistosomiasis. The remaining alleles showed no association with advanced disease. Allele DRB1*1202 co-occurred with allele DQA1*0601; therefore, their independent protective effects could not be ascertained. In contrast, alleles DQA1*0601 and DQB1*05031 never co-occurred and had opposite and significant effects on the occurrence of disease.
KW - Fibrosis
KW - Hepatosplenic disease
KW - HLA Class II antigens
KW - Schistosoma japonicum
KW - Schistosomiasis
KW - Susceptibility/resistance
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U2 - 10.1016/S0020-7519(98)00020-4
DO - 10.1016/S0020-7519(98)00020-4
M3 - Article
C2 - 9602373
AN - SCOPUS:0032055345
VL - 28
SP - 537
EP - 542
JO - International Journal for Parasitology
JF - International Journal for Parasitology
SN - 0020-7519
IS - 4
ER -
