Human cytomegalovirus upregulates expression of the lectin galectin 9 via induction of beta interferon

Brian P. McSharry, Simone K. Forbes, John Z. Cao, Selmir Avdic, Emily A. Machala, David J. Gottlieb, Allison Abendroth, Barry Slobedman

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Regulation of the lectin galectin 9 (Gal-9) was investigated for the first time during human cytomegalovirus (HCMV) infection. Gal-9 transcription was significantly upregulated in transplant recipients with reactivated HCMV in vivo. In vitro, Gal-9 was potently upregulated by HCMV independently of viral gene expression, with interferon beta (IFN-β) identified as the mediator of this effect. This study defines an immunoregulatory protein potently increased by HCMV infection and a novel mechanism to control Gal-9 through IFN-β induction.

Original languageEnglish
Pages (from-to)10990-10994
Number of pages5
JournalJournal of Virology
Volume88
Issue number18
DOIs
Publication statusPublished - Sep 2014

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