Human cytomegalovirus upregulates expression of the lectin galectin 9 via induction of beta interferon

Brian P. McSharry; Simone K. Forbes; John Z. Cao; Selmir Avdic; Emily A. Machala; David J. Gottlieb; Allison Abendroth; Barry Slobedman

doi:10.1128/JVI.01259-14

Human cytomegalovirus upregulates expression of the lectin galectin 9 via induction of beta interferon

Brian P. McSharry, Simone K. Forbes, John Z. Cao, Selmir Avdic, Emily A. Machala, David J. Gottlieb, Allison Abendroth, Barry Slobedman

Dentistry and Medical Sciences

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Regulation of the lectin galectin 9 (Gal-9) was investigated for the first time during human cytomegalovirus (HCMV) infection. Gal-9 transcription was significantly upregulated in transplant recipients with reactivated HCMV in vivo. In vitro, Gal-9 was potently upregulated by HCMV independently of viral gene expression, with interferon beta (IFN-β) identified as the mediator of this effect. This study defines an immunoregulatory protein potently increased by HCMV infection and a novel mechanism to control Gal-9 through IFN-β induction.

Original language	English
Pages (from-to)	10990-10994
Number of pages	5
Journal	Journal of Virology
Volume	88
Issue number	18
DOIs	https://doi.org/10.1128/JVI.01259-14
Publication status	Published - Sept 2014

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title = "Human cytomegalovirus upregulates expression of the lectin galectin 9 via induction of beta interferon",

abstract = "Regulation of the lectin galectin 9 (Gal-9) was investigated for the first time during human cytomegalovirus (HCMV) infection. Gal-9 transcription was significantly upregulated in transplant recipients with reactivated HCMV in vivo. In vitro, Gal-9 was potently upregulated by HCMV independently of viral gene expression, with interferon beta (IFN-β) identified as the mediator of this effect. This study defines an immunoregulatory protein potently increased by HCMV infection and a novel mechanism to control Gal-9 through IFN-β induction.",

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AU - McSharry, Brian P.

AU - Forbes, Simone K.

AU - Cao, John Z.

AU - Avdic, Selmir

AU - Machala, Emily A.

AU - Gottlieb, David J.

AU - Abendroth, Allison

AU - Slobedman, Barry

PY - 2014/9

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AB - Regulation of the lectin galectin 9 (Gal-9) was investigated for the first time during human cytomegalovirus (HCMV) infection. Gal-9 transcription was significantly upregulated in transplant recipients with reactivated HCMV in vivo. In vitro, Gal-9 was potently upregulated by HCMV independently of viral gene expression, with interferon beta (IFN-β) identified as the mediator of this effect. This study defines an immunoregulatory protein potently increased by HCMV infection and a novel mechanism to control Gal-9 through IFN-β induction.

KW - Cytomegalovirus/physiology

KW - Cytomegalovirus Infections/genetics

KW - Galectins/genetics

KW - Host-Pathogen Interactions

KW - Humans

KW - Interferon-beta/genetics

KW - Up-Regulation

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Human cytomegalovirus upregulates expression of the lectin galectin 9 via induction of beta interferon

Abstract

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