TY - JOUR
T1 - Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19
T2 - A novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis
AU - Henry, Brandon Michael
AU - Vikse, Jens
AU - Benoit, Stefanie
AU - Favaloro, Emmanuel J.
AU - Lippi, Giuseppe
PY - 2020/8
Y1 - 2020/8
N2 - Early clinical evidence suggests that severe cases of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are frequently characterized by hyperinflammation, imbalance of renin-angiotensin-aldosterone system, and a particular form of vasculopathy, thrombotic microangiopathy, and intravascular coagulopathy. In this paper, we present an immunothrombosis model of COVID-19. We discuss the underlying pathogenesis and the interaction between multiple systems, resulting in propagation of immunothrombosis, which through investigation in the coming weeks, may lead to both an improved understanding of COVID-19 pathophysiology and identification of innovative and efficient therapeutic targets to reverse the otherwise unfavorable clinical outcome of many of these patients.
AB - Early clinical evidence suggests that severe cases of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are frequently characterized by hyperinflammation, imbalance of renin-angiotensin-aldosterone system, and a particular form of vasculopathy, thrombotic microangiopathy, and intravascular coagulopathy. In this paper, we present an immunothrombosis model of COVID-19. We discuss the underlying pathogenesis and the interaction between multiple systems, resulting in propagation of immunothrombosis, which through investigation in the coming weeks, may lead to both an improved understanding of COVID-19 pathophysiology and identification of innovative and efficient therapeutic targets to reverse the otherwise unfavorable clinical outcome of many of these patients.
KW - Coagulation
KW - Coronavirus
KW - COVID-19
KW - Endothelial dysfunction
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=85083859012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083859012&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2020.04.027
DO - 10.1016/j.cca.2020.04.027
M3 - Comment/debate
C2 - 32348783
AN - SCOPUS:85083859012
SN - 0009-8981
VL - 507
SP - 167
EP - 173
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -
