Hypertension Management and Factors Affecting QT Dispersion in Patients with Hypertension

Fiona White

Research output: ThesisDoctoral Thesis

38 Downloads (Pure)

Abstract

There was a history of smoking in 88 (34.2%) patients, alcohol consumption in 49 (19.1%), and 70 (27.2%) patients were currently overweight or obese. At the time of admission, 62 (24.1%) patients had a blood pressure measurement <140/90mmHg, while at the time of discharge, 136 (59.6%) patients had a blood pressure level <140/90mmHg (p<0.001). Antihypertensive medication use was reported by 246 (95.7%) patients and non-pharmacological options by 107 (41.6%). Use of one (n=76, 29.6%) or two (n=93, 36.2%) antihypertensive medications was common, with the most commonly used classes of antihypertensive at the time of discharge being CCBs (n=192, 74.7%), ACEIs (n=127, 49.4%), diuretics (n=101, 39.3%), and ARBs (n=70, 27.2%).The mean QTc dispersion in this study was 65.7 ± 26.4msec, with a range of 18.3-174.0msec. Multiple regression analysis revealed that the main predicting factor of QTc dispersion in this study was an increased left ventricular mass index (p=0.001). Past use of aspirin, and decreased blood platelets were also found to have some influence (p=0.006 and p=0.005 respectively) on QTc dispersion. Other variables however, such as ejection fraction, age and use of antihypertensive medications were not found to be associated with QTc dispersion (p>0.05).Conclusion: The overall management of hypertension in the patients of this study is suboptimal. Hypertension control was very poor at the time of admission, however showed significant improvement at the time of discharge. The mean QTc dispersion in this study was 65.7 ± 26.4msec. The main influencing factor of QTc dispersion in patients with hypertension was identified as increased left ventricular mass index. The influences of past use of aspirin and decreased blood platelets require further investigation.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Charles Sturt University
Supervisors/Advisors
  • Wang, Lexin, Co-Supervisor
  • Wei, Tiemin, Co-Supervisor
  • Ball, Patrick, Co-Supervisor
Award date01 Aug 2011
Place of PublicationAustralia
Publisher
Publication statusPublished - 2011

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