Identification of epithelial auto-antigens associated with periodontal disease.

P. Ye, M. Simonian, M A. Nadkarni, A A. Decarlo, Cheryl C. Chapple, Neil Hunter

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

We previously reported evidence that patients with periodontitis have serum antibodies to oral Gram positive bacteria that are cross-reactive with epithelial antigens. In the present report cross-reactive epithelial antigens including CD24, lactate dehydrogenase A [LDM-A], antioxidant protein 2 [AOP 2] and nuclear factor of activated T cells 5 [NFAT 5], were identified by screening a cDNA expression library with pooled patient sera. Titres of antibodies to CD24 peptide correlated negatively with indices of periodontal disease severity. Strong expression of CD24 in the reactive periodontal epithelium and inflamed gingival attachment contrasted with low to undetectable expression in the external gingival epithelium. In periodontitis, a local action of these auto-reactive antibodies could modulate the regulatory potential associated with expression of CD24 in this epithelium.
Original languageEnglish
Pages (from-to)328-337
Number of pages10
JournalClinical and Experimental Immunology
Volume140
Issue number1
DOIs
Publication statusPublished - Feb 2005

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