Identification Of Genetic and Epigenetic Alterations In Spondyloarthritis

Tibor A Rauch; Beata Tryniszewska; Andras Vida; Timea Ocsko; Sandor Szanto; Holly L Rosenzweig; Matthew A Brown; Gethin P Thomas; Katalin Mikecz; Tibor T Glant

Identification Of Genetic and Epigenetic Alterations In Spondyloarthritis

Tibor A Rauch, Beata Tryniszewska, Andras Vida, Timea Ocsko, Sandor Szanto, Holly L Rosenzweig, Matthew A Brown, Gethin P Thomas, Katalin Mikecz, Tibor T Glant

University of Queensland

Research output: Other contribution to conference › Abstract › peer-review

Abstract

Ankylosing spondylitis (AS) is the prototypic spondyloarthritis and affects approximately 0.2-0.5% of the human population. It is estimated that genetic risk factors contribute >90% of disease susceptibility, and the major genetic risk factor is HLA-B27. Approximately the other half of the genetic risk is composed by non-MHC traits. By generating interval-specific congenic (IVSC) strains utilizing the genetic combination of proteoglycan-induced SpA (PGISpA) in susceptible BALB/c mice and SpA-resistant DBA/2 mice (both carry the same MHC) we can identify non-MHC causative genes by excluding the effect of the MHC. These IVSC strains with overlapping chromosome (Chr) regions were used to narrow the (Pgis2) risk locus on mouse Chr2 (mChr2) to a small region syntenic with AS risk loci on human chromosomes 4 and 9.

Original language	English
Pages	S1153-S1153
Number of pages	1
Publication status	Published - 2013
Event	2013 ACR/ARHP Annual Meeting - San Diego, United States Duration: 24 Oct 2013 → 29 Oct 2013 https://www.emedevents.com/c/medical-conferences-2013/acr-arhp-annual-meeting-2013

Conference

Conference	2013 ACR/ARHP Annual Meeting
Country/Territory	United States
City	San Diego
Period	24/10/13 → 29/10/13
Internet address	https://www.emedevents.com/c/medical-conferences-2013/acr-arhp-annual-meeting-2013

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Rauch, T. A., Tryniszewska, B., Vida, A., Ocsko, T., Szanto, S., Rosenzweig, H. L., Brown, M. A., Thomas, G. P., Mikecz, K., & Glant, T. T. (2013). Identification Of Genetic and Epigenetic Alterations In Spondyloarthritis. S1153-S1153. Abstract from 2013 ACR/ARHP Annual Meeting, San Diego, California, United States. http://acrabstracts.org/abstract/identification-of-genetic-and-epigenetic-alterations-in-spondyloarthritis/

@conference{d8ecac3df33440a78219180a2083ea6d,

title = "Identification Of Genetic and Epigenetic Alterations In Spondyloarthritis",

abstract = "Ankylosing spondylitis (AS) is the prototypic spondyloarthritis and affects approximately 0.2-0.5% of the human population. It is estimated that genetic risk factors contribute >90% of disease susceptibility, and the major genetic risk factor is HLA-B27. Approximately the other half of the genetic risk is composed by non-MHC traits. By generating interval-specific congenic (IVSC) strains utilizing the genetic combination of proteoglycan-induced SpA (PGISpA) in susceptible BALB/c mice and SpA-resistant DBA/2 mice (both carry the same MHC) we can identify non-MHC causative genes by excluding the effect of the MHC. These IVSC strains with overlapping chromosome (Chr) regions were used to narrow the (Pgis2) risk locus on mouse Chr2 (mChr2) to a small region syntenic with AS risk loci on human chromosomes 4 and 9.",

author = "Rauch, {Tibor A} and Beata Tryniszewska and Andras Vida and Timea Ocsko and Sandor Szanto and Rosenzweig, {Holly L} and Brown, {Matthew A} and Thomas, {Gethin P} and Katalin Mikecz and Glant, {Tibor T}",

year = "2013",

language = "English",

pages = "S1153--S1153",

note = "2013 ACR/ARHP Annual Meeting ; Conference date: 24-10-2013 Through 29-10-2013",

url = "https://www.emedevents.com/c/medical-conferences-2013/acr-arhp-annual-meeting-2013",

}

Rauch, TA, Tryniszewska, B, Vida, A, Ocsko, T, Szanto, S, Rosenzweig, HL, Brown, MA, Thomas, GP, Mikecz, K & Glant, TT 2013, 'Identification Of Genetic and Epigenetic Alterations In Spondyloarthritis', 2013 ACR/ARHP Annual Meeting, San Diego, United States, 24/10/13 - 29/10/13 pp. S1153-S1153. <http://acrabstracts.org/abstract/identification-of-genetic-and-epigenetic-alterations-in-spondyloarthritis/>

TY - CONF

T1 - Identification Of Genetic and Epigenetic Alterations In Spondyloarthritis

AU - Rauch, Tibor A

AU - Tryniszewska, Beata

AU - Vida, Andras

AU - Ocsko, Timea

AU - Szanto, Sandor

AU - Rosenzweig, Holly L

AU - Brown, Matthew A

AU - Thomas, Gethin P

AU - Mikecz, Katalin

AU - Glant, Tibor T

PY - 2013

Y1 - 2013

N2 - Ankylosing spondylitis (AS) is the prototypic spondyloarthritis and affects approximately 0.2-0.5% of the human population. It is estimated that genetic risk factors contribute >90% of disease susceptibility, and the major genetic risk factor is HLA-B27. Approximately the other half of the genetic risk is composed by non-MHC traits. By generating interval-specific congenic (IVSC) strains utilizing the genetic combination of proteoglycan-induced SpA (PGISpA) in susceptible BALB/c mice and SpA-resistant DBA/2 mice (both carry the same MHC) we can identify non-MHC causative genes by excluding the effect of the MHC. These IVSC strains with overlapping chromosome (Chr) regions were used to narrow the (Pgis2) risk locus on mouse Chr2 (mChr2) to a small region syntenic with AS risk loci on human chromosomes 4 and 9.

AB - Ankylosing spondylitis (AS) is the prototypic spondyloarthritis and affects approximately 0.2-0.5% of the human population. It is estimated that genetic risk factors contribute >90% of disease susceptibility, and the major genetic risk factor is HLA-B27. Approximately the other half of the genetic risk is composed by non-MHC traits. By generating interval-specific congenic (IVSC) strains utilizing the genetic combination of proteoglycan-induced SpA (PGISpA) in susceptible BALB/c mice and SpA-resistant DBA/2 mice (both carry the same MHC) we can identify non-MHC causative genes by excluding the effect of the MHC. These IVSC strains with overlapping chromosome (Chr) regions were used to narrow the (Pgis2) risk locus on mouse Chr2 (mChr2) to a small region syntenic with AS risk loci on human chromosomes 4 and 9.

M3 - Abstract

SP - S1153-S1153

T2 - 2013 ACR/ARHP Annual Meeting

Y2 - 24 October 2013 through 29 October 2013

ER -

Identification Of Genetic and Epigenetic Alterations In Spondyloarthritis

Abstract

Conference

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