Ankylosing spondylitis (AS) is the prototypic spondyloarthritis and affects approximately 0.2-0.5% of the human population. It is estimated that genetic risk factors contribute >90% of disease susceptibility, and the major genetic risk factor is HLA-B27. Approximately the other half of the genetic risk is composed by non-MHC traits. By generating interval-specific congenic (IVSC) strains utilizing the genetic combination of proteoglycan-induced SpA (PGISpA) in susceptible BALB/c mice and SpA-resistant DBA/2 mice (both carry the same MHC) we can identify non-MHC causative genes by excluding the effect of the MHC. These IVSC strains with overlapping chromosome (Chr) regions were used to narrow the (Pgis2) risk locus on mouse Chr2 (mChr2) to a small region syntenic with AS risk loci on human chromosomes 4 and 9.
|Number of pages||1|
|Publication status||Published - 2013|
|Event||2013 ACR/ARHP Annual Meeting - San Diego, United States|
Duration: 24 Oct 2013 → 29 Oct 2013
|Conference||2013 ACR/ARHP Annual Meeting|
|Period||24/10/13 → 29/10/13|
Rauch, T. A., Tryniszewska, B., Vida, A., Ocsko, T., Szanto, S., Rosenzweig, H. L., Brown, M. A., Thomas, G. P., Mikecz, K., & Glant, T. T. (2013). Identification Of Genetic and Epigenetic Alterations In Spondyloarthritis. S1153-S1153. Abstract from 2013 ACR/ARHP Annual Meeting, San Diego, United States. http://acrabstracts.org/abstract/identification-of-genetic-and-epigenetic-alterations-in-spondyloarthritis/