Identifying increased risk of post-infarct people with diabetes using multi-lag Tone-Entropy analysis

C. Karmakar, Herbert Jelinek, A. Khandoker, M. Tulppo, T. Makikallio, A. Kiviniemi, H. Huikuri, M. Palaniswami

Research output: Book chapter/Published conference paperConference paper

6 Citations (Scopus)

Abstract

Diabetes mellitus is associated with multi-organ system dysfunction. One of the key causative factors is the increased blood sugar level that leads to an increase in free radical activity and organ damage including the cardiovascular and nervous system. Heart rhythm is extrinsically modulated by the autonomic nervous system and cardiac autonomic neuropathy or dysautonomia has been shown to lead to sudden cardiac death in people with diabetes due to the decrease in heart rate variability (HRV). Current algorithms for determining HRV describe only beat-to-beat variation and therefore do not consider the ability of a heart beat to influence a train of succeeding beats. Therefore mortality risk analysis based on HRV has often not been able to discern the presence of an increased risk. This study used a novel innovation of the tone-entropy algorithm by incorporating increased lag intervals and found that both the sympatho-vagal balance and total activity changed at larger lag intervals. Tone-Entropy was found to be better risk identifier of cardiac mortality in people with diabetes at lags higher than one and best at lag seven.
Original languageEnglish
Title of host publicationProceedings of the 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEMBC 2012
Place of PublicationUnited States
PublisherInstitute of Electrical and Electronics Engineers
Pages25-28
Number of pages4
ISBN (Electronic)9781424441198
DOIs
Publication statusPublished - 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine & Biology Society - Hilton San Diego Bayfront, San Diego, United States
Duration: 28 Aug 201201 Sep 2012
https://web.archive.org/web/20131001043129/http://embc2012.embs.org/ (Archived page)

Conference

Conference34th Annual International Conference of the IEEE Engineering in Medicine & Biology Society
Abbreviated titleEngineering Innovation in Global Health
CountryUnited States
CitySan Diego
Period28/08/1201/09/12
Otherhe 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society will take place at the Hilton Bayfront Hotel in San Diego, California, USA. The general theme of EMBC'12 is "Engineering Innovation in Global Health", covering a broad spectrum of topics in biomedical engineering and healthcare technologies, including medical and clinical applications
Internet address

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