Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels

Andrew J. Delaney, John M. Power, Pankaj Sah

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Ifenprodil is a selective blocker of NMDA receptors that are heterodimers composed of GluN1/GluN2B subunits. This pharmacological profile has been extensively used to test the role of GluN2B-containing NMDA receptors in learning and memory formation. However, ifenprodil has also been reported to have actions at a number of other receptors, including high voltage-activated calcium channels. Here we show that, in the basolateral amygdala, ifenprodil dose dependently blocks excitatory transmission to principal neurons by a presynaptic mechanism. This action of ifenprodil has an IC50 of ~10 'M and is fully occluded by the P/Q type calcium channel blocker '-agatoxin. We conclude that ifenprodil reduces synaptic transmission in the basolateral amygdala by partially blocking P-type voltage-dependent calcium channels.
Original languageEnglish
Pages (from-to)1571-1575
Number of pages5
JournalJournal of Neurophysiology
Volume107
Issue number6
DOIs
Publication statusPublished - Mar 2012

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