Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh

Farhana Khanam; Golap Babu; Nazia Rahman; Xinxue Liu; Nazmul Hasan Rajib; Shams Uddin Ahmed; Md Ismail Hossen; Prasanta Kumar Biswas; Sarah Kelly; Katherine Thesis-Nyland; Yama Mujadidi; Nigel A.J. McMillan; Andrew J. Pollard; John D. Clemens; Firdausi Qadri

doi:10.1016/j.vaccine.2023.04.014

Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh

Farhana Khanam, Golap Babu, Nazia Rahman, Xinxue Liu, Nazmul Hasan Rajib, Shams Uddin Ahmed, Md Ismail Hossen, Prasanta Kumar Biswas, Sarah Kelly, Katherine Thesis-Nyland, Yama Mujadidi, Nigel A.J. McMillan, Andrew J. Pollard, John D. Clemens, Firdausi Qadri

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Abstract

A cluster-randomized trial of Vi-TT was conducted in Dhaka, Bangladesh, using JE vaccine as the control. A subset of 1,500 children were randomly selected on 2:1 basis (Vi-TT vs JE) to assess immune response. Blood was collected before vaccination, and on days 28, 545 and 730 post-vaccination and plasma anti-Vi-IgG response was measured. A robust, persistent antibody response was induced after single dose of Vi-TT, even after 2 years of vaccination. While there is no accepted serological antibody threshold of protection, analyzing the antibodies of children who received Vi-TT provides evidence that may later be useful in predicting population protection.

Original language	English
Pages (from-to)	3137-3140
Number of pages	4
Journal	Vaccine
Volume	41
Issue number	19
DOIs	https://doi.org/10.1016/j.vaccine.2023.04.014
Publication status	Published - 05 May 2023

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10.1016/j.vaccine.2023.04.014

542592319 Published articleFinal published version, 224 KBLicence: CC BY

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Khanam, F., Babu, G., Rahman, N., Liu, X., Rajib, N. H., Ahmed, S. U., Hossen, M. I., Biswas, P. K., Kelly, S., Thesis-Nyland, K., Mujadidi, Y., McMillan, N. A. J., Pollard, A. J., Clemens, J. D., & Qadri, F. (2023). Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh. Vaccine, 41(19), 3137-3140. https://doi.org/10.1016/j.vaccine.2023.04.014

@article{c92382876460424099320860bb93aa9f,

title = "Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh",

abstract = "A cluster-randomized trial of Vi-TT was conducted in Dhaka, Bangladesh, using JE vaccine as the control. A subset of 1,500 children were randomly selected on 2:1 basis (Vi-TT vs JE) to assess immune response. Blood was collected before vaccination, and on days 28, 545 and 730 post-vaccination and plasma anti-Vi-IgG response was measured. A robust, persistent antibody response was induced after single dose of Vi-TT, even after 2 years of vaccination. While there is no accepted serological antibody threshold of protection, analyzing the antibodies of children who received Vi-TT provides evidence that may later be useful in predicting population protection.",

keywords = "Bangladeshi children, CRT-TCV, Long-term immune response",

author = "Farhana Khanam and Golap Babu and Nazia Rahman and Xinxue Liu and Rajib, {Nazmul Hasan} and Ahmed, {Shams Uddin} and Hossen, {Md Ismail} and Biswas, {Prasanta Kumar} and Sarah Kelly and Katherine Thesis-Nyland and Yama Mujadidi and McMillan, {Nigel A.J.} and Pollard, {Andrew J.} and Clemens, {John D.} and Firdausi Qadri",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

month = may,

day = "5",

doi = "10.1016/j.vaccine.2023.04.014",

language = "English",

volume = "41",

pages = "3137--3140",

journal = "Vaccine",

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Khanam, F, Babu, G, Rahman, N, Liu, X, Rajib, NH, Ahmed, SU, Hossen, MI, Biswas, PK, Kelly, S, Thesis-Nyland, K, Mujadidi, Y, McMillan, NAJ, Pollard, AJ, Clemens, JD & Qadri, F 2023, 'Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh', Vaccine, vol. 41, no. 19, pp. 3137-3140. https://doi.org/10.1016/j.vaccine.2023.04.014

TY - JOUR

T1 - Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh

AU - Khanam, Farhana

AU - Babu, Golap

AU - Rahman, Nazia

AU - Liu, Xinxue

AU - Rajib, Nazmul Hasan

AU - Ahmed, Shams Uddin

AU - Hossen, Md Ismail

AU - Biswas, Prasanta Kumar

AU - Kelly, Sarah

AU - Thesis-Nyland, Katherine

AU - Mujadidi, Yama

AU - McMillan, Nigel A.J.

AU - Pollard, Andrew J.

AU - Clemens, John D.

AU - Qadri, Firdausi

PY - 2023/5/5

Y1 - 2023/5/5

N2 - A cluster-randomized trial of Vi-TT was conducted in Dhaka, Bangladesh, using JE vaccine as the control. A subset of 1,500 children were randomly selected on 2:1 basis (Vi-TT vs JE) to assess immune response. Blood was collected before vaccination, and on days 28, 545 and 730 post-vaccination and plasma anti-Vi-IgG response was measured. A robust, persistent antibody response was induced after single dose of Vi-TT, even after 2 years of vaccination. While there is no accepted serological antibody threshold of protection, analyzing the antibodies of children who received Vi-TT provides evidence that may later be useful in predicting population protection.

AB - A cluster-randomized trial of Vi-TT was conducted in Dhaka, Bangladesh, using JE vaccine as the control. A subset of 1,500 children were randomly selected on 2:1 basis (Vi-TT vs JE) to assess immune response. Blood was collected before vaccination, and on days 28, 545 and 730 post-vaccination and plasma anti-Vi-IgG response was measured. A robust, persistent antibody response was induced after single dose of Vi-TT, even after 2 years of vaccination. While there is no accepted serological antibody threshold of protection, analyzing the antibodies of children who received Vi-TT provides evidence that may later be useful in predicting population protection.

KW - Bangladeshi children

KW - CRT-TCV

KW - Long-term immune response

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DO - 10.1016/j.vaccine.2023.04.014

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EP - 3140

JO - Vaccine

JF - Vaccine

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ER -

Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh

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