Impact of carotid artery stenting on plasma interleukin-6, tumor necrosis factor-' and C-reactive protein

Z.-Y.a Xia, H Yang, H.-Q. Qu, W.-D Cheng, Lexin Wang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

AIM:This study aimed to investigate the impact of carotid artery stenting (CAS) on plasma levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-') and C-reactive protein (CRP).METHODS: The levels of CRP, IL-6, and TNF-' were measured in 61 patients before CAS, 1 h, 2 weeks, 1 month, 6 months, and 12 months after the stenting.RESULTS: The levels of CRP, IL-6 and TNF-' increased immediately after CAS (P<0.05 or <0.01). The levels of CRP, IL-6 and TNF-' in patients receiving two stents for multiple lesions or single diffusive lesions was also high than in patients receiving one stent for a single lesion (P<0.05 or <0.01). The levels of CRP, IL-6 and TNF-' in patients with restenosis (14/61, or 23%) were higher than in those without restenosis (P<0.05 or <0.01).CONCLUSION: CAS was associated with a significant increase in plasma CRP, IL-6 and TNF-'. The levels of these inflammatory factors in patients with post-CAS restenosis were higher than in those without restenosis.
Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalInternational Angiology: a journal on angiology
Volume31
Issue number1
Publication statusPublished - Feb 2012

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