Impaired fasting glucose & 8-iso-prostaglandin F2α in diabetes disease progression

Herbert F. Jelinek, Dina A. Jamil, Hayder A. Al-Aubaidy

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Aim: The objective of the present study was to evaluate the changes of 8-isoprostaglandin F2α and other markers of oxidative stress with impaired fasting glucose when compared to non-diabetic control participants.
Methodology: This is a cross-sectional study, conducted at Charles Sturt University, Albury, NSW, Australia and included 428 participants (female: male, 247:181) participants attending the Diabetes Complications Clinic in the School of Community Health for the period between January 2011 to October 2012.
Results: Urinary 8-isoprostaglandin F2α was significantly greater in the impaired fasting glucose group (1.4±1.3ng/ml) compared to control group (0.68±0.5ng/ml, P= .05). The increase in urinary 8-isoprostaglandin F2α was associated with a significant elevation in serum total cholesterol (4.7±1.1mol/L, P= .04) and a significant reduction in high density lipoprotein cholesterol (1.4±0.4mmol/L, P= .02) in the impaired fasting glucose group compared to the control group. A significant negative correlation was noted between urinary 8-isoprostaglandin F2α and high-density lipoprotein cholesterol among all the participants included in this study (P= .05).
Conclusions: The current study proves the importance of measuring markers of oxidative stress, expressed by urinary 8-isoprostaglandin F2α and serum lipids in managing cases of impaired fasting glucose and suggests a useful biomarker for assessing disease progression and/or remission, especially in the prediabetic state.
Original languageEnglish
Pages (from-to)5229-5237
Number of pages9
JournalBritish Journal of Medicine and Medical Research
Issue number33
Publication statusPublished - 2014


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