Improvement of left ventricular remodelling by inhibition of NF-κB in a rat model of myocardial infarction

Jin-lan Jin, Rong-gui Lv, Jian Guo, Xi-hong Liu, Yan-wen Liang, Jian-rui Wei, Lexin Wang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: To investigate the effects of inhibition of NF-?B activation on left ventricular (LV) remodelling in a rat model of myocardial infarction (MI). Methods: The acute MI model was established by ligation of left anterior descending coronary artery. Pyrrolidine dithiocarbamate (PDTC) (20. mg/kg, Qd) was administered intraperitoneally to inhibit NF-?B activation. Eight weeks later, the cardiac structure and LV ejection fraction were assessed with echocardiography. The rat body, heart, and LV weights were measured to calculate LV mass indices. Activation of NF-?B in non-infarcted myocardium was detected by a TransAM NF-?B p65 Transcription Factor Assay Kit. Cardiac collagen volume fraction was evaluated by Masson staining. Results: Eight weeks after the MI model was established, the LV posterior wall thickness in PDTC and MI group was 1.75. ±. 0.07. mm and 1.85. ±. 0.07. mm respectively (p <. 0.05). The LV mass index in the PDTC group (2.53. ±. 0.09) was lower than in the MI group (2.65. ±. 0.08, p <. 0.05). The LVEF in the PDTC group (63.89%. ±. 4.21%) was higher than in the MI group (42.73%. ±. 8.94%, p. <. 0.05). The interstitial collagen deposition in the non-infarcted myocardium in the PDTC group was less than in the MI group (7.25%. ±. 1.88% vs. 10.09%. ±. 2.19%, p <. 0.05). Conclusion: Inhibition of activation of NF-?B may result in improvement of myocardial remodelling after myocardial infarction, which is possibly attributable to reduced collagen deposition in non-infarcted areas.
Original languageEnglish
Pages (from-to)1007-1012
Number of pages6
JournalHeart Lung and Circulation
Volume25
Issue number10
Early online dateNov 2015
DOIs
Publication statusPublished - Oct 2016

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