Increased expression of the PRL-3 gene in human oral squamous cell carcinoma and dysplasia tissues

Nur Hassan, Jun-ichi Hamada, Takeshi Kameyama, Mitsuhiro Tada, Koji Nakagawa, Shoko Yoshida, Haruhiko Kashiwazaki, Yutaka Yamazaki, Yukiko Suzuki, Akira Sasaki, Hitoshi Nagatsuka, Nobuo Inoue, Tetsuya Moriuchi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Phosphatase of regenerating liver (PRL) belongs to a class of the protein tyrosine phosphatase family, which is known so far to consist of 3 members, PRL-1, PRL-2, and PRL-3. The aim of this study was to uncover the role of PRL genes in development of oral malignancy. We analyzed expression levels of the 3 PRL genes in 50 human oral squamous cell carcinomas (OSCCs), 11 dysplasia and 12 normal mucosa tissues by a real-time RT-PCR method. PRL-3 but not PRL-1 or PRL-2 expressions were significantly higher in OSCC and dysplasia than in normal mucosa tissues. Additionally, PRL-3 expressions were significantly higher in OSCC tissues harboring dominant-negative p53 or recessive p53 mutation than in those harboring wild-type p53. These results suggest that PRL-3 plays a role in oral cancer development and can be useful as a marker of pre-malignant and malignant lesion of oral mucosa.
Original languageEnglish
Pages (from-to)947-951
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume12
Issue number4
Early online date2010
Publication statusPublished - Apr 2011

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