Increased prostaglandin response to oxytocin in ewes fed a diet high in omega-6 polyunsaturated fatty acids

Catherine Gulliver, Michael Friend, Belinda King, Susan Robertson, John Wilkins, Edward Clayton

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Diets high in omega-6 polyunsaturated fatty acids (n-6) are associated with increased prostaglandin F2α (PGF2α) synthesis in cattle, however, the specific effects on the potential prostaglandin response to an oxytocin challenge in sheep have not been reported. The aim of the current study was to determine whether oxytocin-stimulated PGF2α was significantly increased when ewes were fed a diet high in n-6 compared with a control diet low in n-6. Merino x Border Leicester ewes (n = 30) received one of two dietary treatments, either high in n-6 (70 % oat grain) or low in n-6 (control diet, 100 % cereal/legume silage). Ewes consumed the diets for 44 days prior to two consecutive oxytocin challenges. Plasma n-6 and PGF2α metabolite (PGFM) concentrations following oxytocin challenge were greater (P < 0.05) when ewes were fed a diet high in n-6 compared with the control diet. A higher availability of n-6 may have lead to an increased in vivo synthesis of PGF2α, however, further research is required to determine the exact mechanisms involved.
Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalLipids
Volume48
Issue number2
Early online dateDec 2012
DOIs
Publication statusPublished - Feb 2013

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