Inflammation-driven bone formation in a mouse model of ankylosing spondylitis: Sequential not parallel processes

Hsu-Wen Tseng, Miranda E Pitt, Tibor T Glant, Allan F McRae, Tony J Kenna, Matthew A Brown, Allison R Pettit, Gethin P Thomas

    Research output: Contribution to journalArticle

    16 Citations (Scopus)
    2 Downloads (Pure)

    Abstract

    Ankylosing spondylitis (AS) is an immune-mediated arthritis particularly targeting the spine and pelvis and is characterised by inflammation, osteoproliferation and frequently ankylosis. Current treatments that predominately target inflammatory pathways have disappointing efficacy in slowing disease progression. Thus, a better understanding of the causal association and pathological progression from inflammation to bone formation, particularly whether inflammation directly initiates osteoproliferation, is required.
    Original languageEnglish
    Article number35
    Pages (from-to)1-12
    Number of pages12
    JournalArthritis Research and Therapy
    Volume18
    Issue number35
    DOIs
    Publication statusPublished - 2016

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