Inhibitory effects of pulse bioactive compounds on cancer development pathways

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Abstract

Previous studies suggest that pulses may have the potential to protect against cancer development by inhibiting pathways that result in the development of cancer. These pathways include those that result in inflammation, DNA damage, cell proliferation, and metastasis. Other studies have demonstrated extracts from pulses have the capacity to induce apoptosis specifically in cancer cells. Compounds reported to be responsible for these activities have included phenolic compounds, proteins and short chain fatty acids. The majority of the studies have been undertaken using in vitro cell culture models, however, there are a small number of in vivo studies that support the hypothesis that pulse consumption may inhibit cancer development. This review highlights the potential benefit of a diet rich in pulse bioactive compounds by exploring the anti-cancer properties of its polyphenols, proteins and short chain fatty acids
Original languageEnglish
Article number72
Pages (from-to)1-15
Number of pages15
JournalDiseases
Volume6
Issue number3
DOIs
Publication statusPublished - 03 Aug 2018

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Volatile Fatty Acids
Neoplasms
Polyphenols
DNA Damage
Proteins
Cell Culture Techniques
Cell Proliferation
Apoptosis
Neoplasm Metastasis
Diet
Inflammation
In Vitro Techniques

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title = "Inhibitory effects of pulse bioactive compounds on cancer development pathways",
abstract = "Previous studies suggest that pulses may have the potential to protect against cancer development by inhibiting pathways that result in the development of cancer. These pathways include those that result in inflammation, DNA damage, cell proliferation, and metastasis. Other studies have demonstrated extracts from pulses have the capacity to induce apoptosis specifically in cancer cells. Compounds reported to be responsible for these activities have included phenolic compounds, proteins and short chain fatty acids. The majority of the studies have been undertaken using in vitro cell culture models, however, there are a small number of in vivo studies that support the hypothesis that pulse consumption may inhibit cancer development. This review highlights the potential benefit of a diet rich in pulse bioactive compounds by exploring the anti-cancer properties of its polyphenols, proteins and short chain fatty acids",
author = "Shiwangni Rao and Kenneth Chinkwo and Abishek Santhakumar and Christopher Blanchard",
year = "2018",
month = "8",
day = "3",
doi = "10.3390/diseases6030072",
language = "English",
volume = "6",
pages = "1--15",
journal = "Diseases",
issn = "2079-9721",
number = "3",

}

TY - JOUR

T1 - Inhibitory effects of pulse bioactive compounds on cancer development pathways

AU - Rao, Shiwangni

AU - Chinkwo, Kenneth

AU - Santhakumar, Abishek

AU - Blanchard, Christopher

PY - 2018/8/3

Y1 - 2018/8/3

N2 - Previous studies suggest that pulses may have the potential to protect against cancer development by inhibiting pathways that result in the development of cancer. These pathways include those that result in inflammation, DNA damage, cell proliferation, and metastasis. Other studies have demonstrated extracts from pulses have the capacity to induce apoptosis specifically in cancer cells. Compounds reported to be responsible for these activities have included phenolic compounds, proteins and short chain fatty acids. The majority of the studies have been undertaken using in vitro cell culture models, however, there are a small number of in vivo studies that support the hypothesis that pulse consumption may inhibit cancer development. This review highlights the potential benefit of a diet rich in pulse bioactive compounds by exploring the anti-cancer properties of its polyphenols, proteins and short chain fatty acids

AB - Previous studies suggest that pulses may have the potential to protect against cancer development by inhibiting pathways that result in the development of cancer. These pathways include those that result in inflammation, DNA damage, cell proliferation, and metastasis. Other studies have demonstrated extracts from pulses have the capacity to induce apoptosis specifically in cancer cells. Compounds reported to be responsible for these activities have included phenolic compounds, proteins and short chain fatty acids. The majority of the studies have been undertaken using in vitro cell culture models, however, there are a small number of in vivo studies that support the hypothesis that pulse consumption may inhibit cancer development. This review highlights the potential benefit of a diet rich in pulse bioactive compounds by exploring the anti-cancer properties of its polyphenols, proteins and short chain fatty acids

U2 - 10.3390/diseases6030072

DO - 10.3390/diseases6030072

M3 - Review article

C2 - 30081504

VL - 6

SP - 1

EP - 15

JO - Diseases

JF - Diseases

SN - 2079-9721

IS - 3

M1 - 72

ER -