Innate immunity of mice to Hendra virus infection

Research output: ThesisDoctoral Thesis

Abstract

Hendra virus (HeV) causes severe infection in a broad range of species leading to mortality in both humans and animals. Productive HeV infection occurred in wild type and mice deficient in interferon signalling (the body’s antiviral defence mechanism). But, unlike other animal species susceptible to HeV infection severe disease did not develop. Therefore the restriction of fulminating disease cannot be attributed solely to the efficacy of mouse interferon signalling pathways against HeV-mediated anti-interferon mechanisms. Little neutralising antibody response was seen, suggesting an innate response mechanism remains relevant to limiting the systemic effects of infection. IFITM proteins were possible candidates but replication and cytopathic effect continued in their presence.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Monash University
Supervisors/Advisors
  • Middleton, Deborah, Co-Supervisor, External person
  • Marsh, Glenn, Co-Supervisor, External person
  • Hertzog, Paul, Principal Supervisor, External person
Thesis sponsors
Award date08 Jun 2018
Publication statusPublished - 2018

Fingerprint

Hendra Virus
Virus Diseases
Innate Immunity
Interferons
Infection
Neutralizing Antibodies
Antibody Formation
Antiviral Agents
Mortality
Proteins

Cite this

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title = "Innate immunity of mice to Hendra virus infection",
abstract = "Hendra virus (HeV) causes severe infection in a broad range of species leading to mortality in both humans and animals. Productive HeV infection occurred in wild type and mice deficient in interferon signalling (the body’s antiviral defence mechanism). But, unlike other animal species susceptible to HeV infection severe disease did not develop. Therefore the restriction of fulminating disease cannot be attributed solely to the efficacy of mouse interferon signalling pathways against HeV-mediated anti-interferon mechanisms. Little neutralising antibody response was seen, suggesting an innate response mechanism remains relevant to limiting the systemic effects of infection. IFITM proteins were possible candidates but replication and cytopathic effect continued in their presence.",
keywords = "Hendra virus, mice, innate immunity",
author = "Emma Croser",
year = "2018",
language = "English",
school = "Monash University",

}

Croser, E 2018, 'Innate immunity of mice to Hendra virus infection', Doctor of Philosophy, Monash University.

Innate immunity of mice to Hendra virus infection. / Croser, Emma.

2018. 267 p.

Research output: ThesisDoctoral Thesis

TY - THES

T1 - Innate immunity of mice to Hendra virus infection

AU - Croser, Emma

PY - 2018

Y1 - 2018

N2 - Hendra virus (HeV) causes severe infection in a broad range of species leading to mortality in both humans and animals. Productive HeV infection occurred in wild type and mice deficient in interferon signalling (the body’s antiviral defence mechanism). But, unlike other animal species susceptible to HeV infection severe disease did not develop. Therefore the restriction of fulminating disease cannot be attributed solely to the efficacy of mouse interferon signalling pathways against HeV-mediated anti-interferon mechanisms. Little neutralising antibody response was seen, suggesting an innate response mechanism remains relevant to limiting the systemic effects of infection. IFITM proteins were possible candidates but replication and cytopathic effect continued in their presence.

AB - Hendra virus (HeV) causes severe infection in a broad range of species leading to mortality in both humans and animals. Productive HeV infection occurred in wild type and mice deficient in interferon signalling (the body’s antiviral defence mechanism). But, unlike other animal species susceptible to HeV infection severe disease did not develop. Therefore the restriction of fulminating disease cannot be attributed solely to the efficacy of mouse interferon signalling pathways against HeV-mediated anti-interferon mechanisms. Little neutralising antibody response was seen, suggesting an innate response mechanism remains relevant to limiting the systemic effects of infection. IFITM proteins were possible candidates but replication and cytopathic effect continued in their presence.

KW - Hendra virus

KW - mice

KW - innate immunity

M3 - Doctoral Thesis

ER -