Introduction: Validation studies for QGS have focussed on the correlation between quantitative measurements of gated SPECT myocardial perfusion imaging and the various modalities providing functional parameters. A detailed investigation of the inter- and intra-operator reproducibility of LVEF is yet to be reported in the literature. Methodology: Each of 50 gated SPECT data sets (25 rest and 25 stress) were each reconstructed and quantitated with automated QGS to determine the LVEF by two independent, experienced technologist operators blinded to previous results and those of the other operator. The 50 data sets were re-analysed by the same operators not less than 80 days after the initial data analysis. Results: Combined rest and stress data for the two independent operators showed a mean LVEF of 49.46% for the first analysis and 49.56% for the second analysis. No statistically significant difference was noted in the mean difference of 0.10% (P = 0.94) and no statistically significant difference was noted between matched pairs (P = 0.49). Excellent correlation was noted with a correlation coefficient of 0.994. A mean LVEF of 49.46% was shown for the first operator and 49.46 for the second operator. No statistically significant difference was noted in the mean difference of 0.00% (P = 1.00) and no statistically significant difference was noted between matched pairs (P = 1.00). Excellent correlation was noted with a correlation coefficient of 0.994. Conclusion: QGS has been shown to demonstrate excellent reproducibility. Furthermore, the QGS determined LVEF is robust temporally allowing raw data to be accurately re-analysed after a period of time has elapsed.
|Number of pages||3|
|Journal||ANZ Nuclear Medicine|
|Publication status||Published - 2006|