Interaction based functional clustering of genomic data

Ritesh Krishna, Chang Tsun Li, Vicky Buchanan-Wollaston

Research output: Book chapter/Published conference paperConference paperpeer-review

1 Citation (Scopus)

Abstract

We present the first report on Granger causality based detection of functional modules from temporal gene expression data. The approach uses temporal causal relationships shared between pair of genes to derive a connection matrix, which is further analyzed using graph-theoretic techniques. The approach is evaluated against a synthesized dataset and a real biological dataset obtained for Arabidopsis thaliana. We show the effectiveness of our approach by analyzing the results using the existing biological literature.

Original languageEnglish
Title of host publicationProceedings of the 2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009
Pages130-137
Number of pages8
DOIs
Publication statusPublished - 2009
Event2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009 - Taichung, Taiwan, Province of China
Duration: 22 Jun 200924 Jun 2009

Conference

Conference2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009
CountryTaiwan, Province of China
CityTaichung
Period22/06/0924/06/09

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