Interaction based functional clustering of genomic data

Ritesh Krishna, Chang Tsun Li, Vicky Buchanan-Wollaston

    Research output: Book chapter/Published conference paperConference paperpeer-review

    1 Citation (Scopus)

    Abstract

    We present the first report on Granger causality based detection of functional modules from temporal gene expression data. The approach uses temporal causal relationships shared between pair of genes to derive a connection matrix, which is further analyzed using graph-theoretic techniques. The approach is evaluated against a synthesized dataset and a real biological dataset obtained for Arabidopsis thaliana. We show the effectiveness of our approach by analyzing the results using the existing biological literature.

    Original languageEnglish
    Title of host publicationProceedings of the 2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009
    Pages130-137
    Number of pages8
    DOIs
    Publication statusPublished - 2009
    Event2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009 - Taichung, Taiwan, Province of China
    Duration: 22 Jun 200924 Jun 2009

    Conference

    Conference2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009
    Country/TerritoryTaiwan, Province of China
    CityTaichung
    Period22/06/0924/06/09

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