Investigating the role of muscarinic acetylcholine M2 and serotonin 5-HT2B receptors, norepinephrine transporter and Kir channels in a pentylenetetrazol-kindling model of epilepsy

Villa Chiara; Enes Akyuz; Zuleyha Doganyigit; Yam Nath Paudel; Betul Koklu; Emin Kaymak; Alina Arulsamy; Mohd. Farooq Shaikh; Orrin Devinsky

doi:10.1016/j.jns.2021.117714

Investigating the role of muscarinic acetylcholine M2 and serotonin 5-HT2B receptors, norepinephrine transporter and Kir channels in a pentylenetetrazol-kindling model of epilepsy

Villa Chiara, Enes Akyuz, Zuleyha Doganyigit, Yam Nath Paudel, Betul Koklu, Emin Kaymak, Alina Arulsamy, Mohd. Farooq Shaikh, Orrin Devinsky

Science and Health

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Epilepsy encompasses a group of neurological disorders characterized by an imbalance of electrical activity in the central nervous system (CNS) and recurrent seizures representing the principal clinical manifestation. Acetylcholine (ACh), serotonin, and norepinephrine (NE) may modulate neural activity via several mechanisms, mainly through its receptors/transporter activity and alterations in the extracellular potassium (K+) concentration via inwardly rectifying K+ (Kir) channels. Therefore, the aim of this study was to investigate the immunoreactivity pattern of these neurotransmitter, receptors/transporters and Kir channels in Pentylenetetrazol (PTZ)-kindling rat model, a well-established tool for studying chronic epilepsy.

Original language	English
Article number	117714
Pages (from-to)	36-37
Number of pages	2
Journal	Journal of the Neurological Sciences
Volume	429
DOIs	https://doi.org/10.1016/j.jns.2021.117714
Publication status	Published - Oct 2021

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10.1016/j.jns.2021.117714

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Chiara, V., Akyuz, E., Doganyigit, Z., Paudel, Y. N., Koklu, B., Kaymak, E., Arulsamy, A., Shaikh, M. F., & Devinsky, O. (2021). Investigating the role of muscarinic acetylcholine M2 and serotonin 5-HT2B receptors, norepinephrine transporter and Kir channels in a pentylenetetrazol-kindling model of epilepsy. Journal of the Neurological Sciences, 429, 36-37. Article 117714. https://doi.org/10.1016/j.jns.2021.117714

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title = "Investigating the role of muscarinic acetylcholine M2 and serotonin 5-HT2B receptors, norepinephrine transporter and Kir channels in a pentylenetetrazol-kindling model of epilepsy",

abstract = "Epilepsy encompasses a group of neurological disorders characterized by an imbalance of electrical activity in the central nervous system (CNS) and recurrent seizures representing the principal clinical manifestation. Acetylcholine (ACh), serotonin, and norepinephrine (NE) may modulate neural activity via several mechanisms, mainly through its receptors/transporter activity and alterations in the extracellular potassium (K+) concentration via inwardly rectifying K+ (Kir) channels. Therefore, the aim of this study was to investigate the immunoreactivity pattern of these neurotransmitter, receptors/transporters and Kir channels in Pentylenetetrazol (PTZ)-kindling rat model, a well-established tool for studying chronic epilepsy.",

author = "Villa Chiara and Enes Akyuz and Zuleyha Doganyigit and Paudel, {Yam Nath} and Betul Koklu and Emin Kaymak and Alina Arulsamy and Shaikh, {Mohd. Farooq} and Orrin Devinsky",

year = "2021",

month = oct,

doi = "10.1016/j.jns.2021.117714",

language = "English",

volume = "429",

pages = "36--37",

journal = "Journal of the Neurological Sciences",

issn = "0022-510X",

publisher = "Elsevier B.V.",

}

Chiara, V, Akyuz, E, Doganyigit, Z, Paudel, YN, Koklu, B, Kaymak, E, Arulsamy, A, Shaikh, MF & Devinsky, O 2021, 'Investigating the role of muscarinic acetylcholine M2 and serotonin 5-HT2B receptors, norepinephrine transporter and Kir channels in a pentylenetetrazol-kindling model of epilepsy', Journal of the Neurological Sciences, vol. 429, 117714, pp. 36-37. https://doi.org/10.1016/j.jns.2021.117714

Investigating the role of muscarinic acetylcholine M2 and serotonin 5-HT2B receptors, norepinephrine transporter and Kir channels in a pentylenetetrazol-kindling model of epilepsy. / Chiara, Villa; Akyuz, Enes; Doganyigit, Zuleyha et al.
In: Journal of the Neurological Sciences, Vol. 429, 117714, 10.2021, p. 36-37.

Research output: Contribution to journal › Meeting Abstract › peer-review

TY - JOUR

T1 - Investigating the role of muscarinic acetylcholine M2 and serotonin 5-HT2B receptors, norepinephrine transporter and Kir channels in a pentylenetetrazol-kindling model of epilepsy

AU - Chiara, Villa

AU - Akyuz, Enes

AU - Doganyigit, Zuleyha

AU - Paudel, Yam Nath

AU - Koklu, Betul

AU - Kaymak, Emin

AU - Arulsamy, Alina

AU - Shaikh, Mohd. Farooq

AU - Devinsky, Orrin

PY - 2021/10

Y1 - 2021/10

N2 - Epilepsy encompasses a group of neurological disorders characterized by an imbalance of electrical activity in the central nervous system (CNS) and recurrent seizures representing the principal clinical manifestation. Acetylcholine (ACh), serotonin, and norepinephrine (NE) may modulate neural activity via several mechanisms, mainly through its receptors/transporter activity and alterations in the extracellular potassium (K+) concentration via inwardly rectifying K+ (Kir) channels. Therefore, the aim of this study was to investigate the immunoreactivity pattern of these neurotransmitter, receptors/transporters and Kir channels in Pentylenetetrazol (PTZ)-kindling rat model, a well-established tool for studying chronic epilepsy.

AB - Epilepsy encompasses a group of neurological disorders characterized by an imbalance of electrical activity in the central nervous system (CNS) and recurrent seizures representing the principal clinical manifestation. Acetylcholine (ACh), serotonin, and norepinephrine (NE) may modulate neural activity via several mechanisms, mainly through its receptors/transporter activity and alterations in the extracellular potassium (K+) concentration via inwardly rectifying K+ (Kir) channels. Therefore, the aim of this study was to investigate the immunoreactivity pattern of these neurotransmitter, receptors/transporters and Kir channels in Pentylenetetrazol (PTZ)-kindling rat model, a well-established tool for studying chronic epilepsy.

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DO - 10.1016/j.jns.2021.117714

M3 - Meeting Abstract

SN - 0022-510X

VL - 429

SP - 36

EP - 37

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

M1 - 117714

ER -

Investigating the role of muscarinic acetylcholine M2 and serotonin 5-HT2B receptors, norepinephrine transporter and Kir channels in a pentylenetetrazol-kindling model of epilepsy

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