TY - JOUR
T1 - Is 6-shogaol an effective phytochemical for patients with lower-risk myelodysplastic syndrome?
T2 - A narrative review
AU - Ooi, Soo Liang
AU - Campbell, Ron
AU - Pak, Sok Cheon
AU - Golombick, Terry
AU - Manoharan, Arumugam
AU - Ramakrishna, Raj
AU - Badmaev, Vladimir
AU - Schloss, Janet
N1 - Funding Information:
In the spirit of reconciliation, the authors acknowledge the Traditional Custodians of country throughout Australia and their connections to land, sea and community. We pay our respect to their Elders past and present and extend that respect to all Aboriginal and Torres Strait Islander peoples today. The author(s) received no financial support for the research, authorship, and/or publication of this article.
Publisher Copyright:
© The Author(s) 2021.
Includes bibliographical references
PY - 2021/12/21
Y1 - 2021/12/21
N2 - Myelodysplastic syndrome (MDS) evolves due to genomic instability, dysregulated signaling pathways, and overproduction of inflammatory markers. Reactive oxygen species contribute to the inflammatory response, which causes gene damage, cellular remodeling, and fibrosis. MDS can be a debilitating condition, and management options in patients with MDS aim to improve cytopenias, delay disease progression, and enhance quality of life. High serum ferritin levels, a source of iron for reactive oxygen species production, correlate with a higher risk of progression to acute myeloid leukemia, and iron overload is compounded by blood transfusions given to improve anemia. 6-shogaol is a natural phenolic compound formed when ginger is exposed to heat and/or acidic conditions, and it has been shown to possess anti-tumor activity against leukemia cell lines and antioxidant effects. This narrative review assessed the potential benefits of this phytochemical in lower-risk MDS patients through examining the current evidence on the pharmacological and therapeutic properties of ginger and 6-shogaol.
AB - Myelodysplastic syndrome (MDS) evolves due to genomic instability, dysregulated signaling pathways, and overproduction of inflammatory markers. Reactive oxygen species contribute to the inflammatory response, which causes gene damage, cellular remodeling, and fibrosis. MDS can be a debilitating condition, and management options in patients with MDS aim to improve cytopenias, delay disease progression, and enhance quality of life. High serum ferritin levels, a source of iron for reactive oxygen species production, correlate with a higher risk of progression to acute myeloid leukemia, and iron overload is compounded by blood transfusions given to improve anemia. 6-shogaol is a natural phenolic compound formed when ginger is exposed to heat and/or acidic conditions, and it has been shown to possess anti-tumor activity against leukemia cell lines and antioxidant effects. This narrative review assessed the potential benefits of this phytochemical in lower-risk MDS patients through examining the current evidence on the pharmacological and therapeutic properties of ginger and 6-shogaol.
KW - (max 6) Zingiber officinale
KW - 6-gingerol
KW - 6-Shogaol
KW - anemia
KW - hematopoiesis
KW - hepcidin
UR - http://www.scopus.com/inward/record.url?scp=85121863922&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85121863922&partnerID=8YFLogxK
U2 - 10.1177/15347354211065038
DO - 10.1177/15347354211065038
M3 - Review article
C2 - 34930049
AN - SCOPUS:85121863922
SN - 1534-7354
VL - 20
SP - 1
EP - 12
JO - Integrative Cancer Therapies
JF - Integrative Cancer Therapies
ER -
