Is gliomatosis peritonei derived from the associated ovarian teratoma?

Queen Elizabeth Hospital, Kowloon, Hong Kong Man-Yee Kwan, Wouter Kalle, Queen Elizabeth Hospital, Kowloon, Hong Kong Gene T.C Lau, Queen Elizabeth Hospital, Kowloon, Hong Kong John K.C Chan

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Gliomatosis peritonei, a rare condition that occurs almost exclusively in the setting of ovarian immature teratoma, is characterized by the occurrence of nodules of mature glial tissues in the peritoneum. It is controversial whether glial tissues are derived from maturation of the associated teratomatous tissue that has implanted in the peritoneum, or glial differentiation of subperitoneal stem cells. In this study, we employed the unique genetic characteristics of ovarian teratomas (often with a duplicated set of maternal chromosomes and thus homozygous at many polymorphic microsatellite loci) versus normal tissues (heterozygous pattern due to presence of maternal and paternal genetic materials) to investigate the origin of gliomatosis peritonei. DNA samples were extracted from microdissected paraffin-embedded tissues, including the glial implants, the associated ovarian teratomas, and normal tissues, to determine their patterns of microsatellite loci in a multiplex polymerase chain reaction system. Two cases were not informative because the ovarian teratoma showed a heterozygous microsatellite pattern. In the 5 informative cases, the normal tissues showed a heterozygous pattern in the microsatellite loci, the associated teratomas showed a homozygous pattern, and the glial tissues showed a heterozygous pattern. Thus, gliomatosis peritonei is genetically unrelated to the associated teratoma but is probably derived from nonteratomatous cells, such as through metaplasia of submesothelial cells.
Original languageEnglish
Pages (from-to)685-688
Number of pages4
JournalHuman Pathology
Issue number6
Publication statusPublished - 2004


Dive into the research topics of 'Is gliomatosis peritonei derived from the associated ovarian teratoma?'. Together they form a unique fingerprint.

Cite this