Isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from cats

Sam Abraham, Mark O'Dea, Darren Trott, Rebecca Abraham, David Hughes, Stanley Pang, Genevieve McKew, Elaine Cheong, John Merlino, Sugiyono Saputra, Richard Malik, Thomas Gottlieb

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Abstract

Carbapenem-resistant Enterobacteriaceae (CRE) are a pressing public health issue due to limited therapeutic options to treat such infections. CREs have been predominantly isolated from humans and environmental samples and they are rarely reported among companion animals. In this study we report on the isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from a companion animal. Carbapenemase-producing S. enterica Typhimurium carrying blaIMP-4 was identified from a systemically unwell (index) cat and three additional cats at an animal shelter. All isolates were identical and belonged to ST19. Genome sequencing revealed the acquisition of a multidrug-resistant IncHI2 plasmid (pIMP4-SEM1) that encoded resistance to nine antimicrobial classes including carbapenems and carried the blaIMP-4-qacG-aacA4-catB3 cassette array.
Original languageEnglish
Article number35527
Pages (from-to)1-7
Number of pages7
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 21 Oct 2016

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    Abraham, S., O'Dea, M., Trott, D., Abraham, R., Hughes, D., Pang, S., McKew, G., Cheong, E., Merlino, J., Saputra, S., Malik, R., & Gottlieb, T. (2016). Isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from cats. Scientific Reports, 6, 1-7. [35527]. https://doi.org/10.1038/srep35527