Kisspeptin and the regulation of the reproductive axis in domestic animals

Research output: Contribution to journalReview article

Abstract

The control of reproductive processes involves the integration of a number of factors from the internal and external environment, with the final output signal of these processes being the pulsatile secretion of gonadotrophin-releasing hormone (GnRH) from the hypothalamus. These factors include the feedback actions of sex steroids, feed intake and nutritional status, season/photoperiod, pheromones, age and stress. Understanding these factors and how they influence GnRH secretion and hence reproduction is important for the management of farm animals. There is evidence that the RF-amide neuropeptide, kisspeptin, may be involved in relaying the effects of these factors to the GnRH neurons. This paper will review the evidence from the common domestic animals (sheep, goats, cattle, horses and pigs), that kisspeptin neurons are (i) regulated by the factors listed above, (ii) contact GnRH neurons and (iii) involved in the regulation of GnRH/gonadotrophin secretion.
LanguageEnglish
PagesR1-R16
Number of pages16
JournalJournal of Endocrinology
Volume240
DOIs
Publication statusPublished - 2018

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Kisspeptins
Domestic Animals
Gonadotropin-Releasing Hormone
Neurons
Domestic Sheep
Pheromones
Photoperiod
Neuropeptides
Nutritional Status
Gonadotropins
Goats
Amides
Hypothalamus
Horses
Reproduction
Swine
Steroids

Cite this

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title = "Kisspeptin and the regulation of the reproductive axis in domestic animals",
abstract = "The control of reproductive processes involves the integration of a number of factors from the internal and external environment, with the final output signal of these processes being the pulsatile secretion of gonadotrophin-releasing hormone (GnRH) from the hypothalamus. These factors include the feedback actions of sex steroids, feed intake and nutritional status, season/photoperiod, pheromones, age and stress. Understanding these factors and how they influence GnRH secretion and hence reproduction is important for the management of farm animals. There is evidence that the RF-amide neuropeptide, kisspeptin, may be involved in relaying the effects of these factors to the GnRH neurons. This paper will review the evidence from the common domestic animals (sheep, goats, cattle, horses and pigs), that kisspeptin neurons are (i) regulated by the factors listed above, (ii) contact GnRH neurons and (iii) involved in the regulation of GnRH/gonadotrophin secretion.",
keywords = "Kisspeptin, GnRH, Hypothalamus, Domestic animals",
author = "Christopher Scott and Jessica Rose and Allan Gunn and Briony McGrath",
year = "2018",
doi = "10.1530/JOE-18-0485",
language = "English",
volume = "240",
pages = "R1--R16",
journal = "Journal of Endocrinology",
issn = "0022-0795",
publisher = "BioScientifica Ltd.",

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TY - JOUR

T1 - Kisspeptin and the regulation of the reproductive axis in domestic animals

AU - Scott, Christopher

AU - Rose, Jessica

AU - Gunn, Allan

AU - McGrath, Briony

PY - 2018

Y1 - 2018

N2 - The control of reproductive processes involves the integration of a number of factors from the internal and external environment, with the final output signal of these processes being the pulsatile secretion of gonadotrophin-releasing hormone (GnRH) from the hypothalamus. These factors include the feedback actions of sex steroids, feed intake and nutritional status, season/photoperiod, pheromones, age and stress. Understanding these factors and how they influence GnRH secretion and hence reproduction is important for the management of farm animals. There is evidence that the RF-amide neuropeptide, kisspeptin, may be involved in relaying the effects of these factors to the GnRH neurons. This paper will review the evidence from the common domestic animals (sheep, goats, cattle, horses and pigs), that kisspeptin neurons are (i) regulated by the factors listed above, (ii) contact GnRH neurons and (iii) involved in the regulation of GnRH/gonadotrophin secretion.

AB - The control of reproductive processes involves the integration of a number of factors from the internal and external environment, with the final output signal of these processes being the pulsatile secretion of gonadotrophin-releasing hormone (GnRH) from the hypothalamus. These factors include the feedback actions of sex steroids, feed intake and nutritional status, season/photoperiod, pheromones, age and stress. Understanding these factors and how they influence GnRH secretion and hence reproduction is important for the management of farm animals. There is evidence that the RF-amide neuropeptide, kisspeptin, may be involved in relaying the effects of these factors to the GnRH neurons. This paper will review the evidence from the common domestic animals (sheep, goats, cattle, horses and pigs), that kisspeptin neurons are (i) regulated by the factors listed above, (ii) contact GnRH neurons and (iii) involved in the regulation of GnRH/gonadotrophin secretion.

KW - Kisspeptin

KW - GnRH

KW - Hypothalamus

KW - Domestic animals

U2 - 10.1530/JOE-18-0485

DO - 10.1530/JOE-18-0485

M3 - Review article

VL - 240

SP - R1-R16

JO - Journal of Endocrinology

T2 - Journal of Endocrinology

JF - Journal of Endocrinology

SN - 0022-0795

ER -