L-carnitine as an adjunct therapy to percutaneous coronary intervention for Non-ST Elevation Myocardial Infarction

Yuzeng Xue, Lexin Wang, Hua-Zhi Liu, Xue-Wen Qi, Xiao-Hua Wang, Hai-Zhou Ren

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Abstract

Objectives: To evaluate the effects of L-carnitine as an adjunct therapy to percutanenous coronary intervention (PCI) for non-ST elevation acute coronary syndrome (NSTEMI).Methods: Ninety-six consecutive patients with NSTEMI were randomized into treatment group (L-carnitine 5 g IV bolus followed by 10 g/day IV infusion for three days), and control group. All patients also underwent PCI within 24h from the onset of chest pain. The peak values of creatine kinase-MB and troponin-I before and after PCI were observed. Results: In the treatment group, the peak values of creatine kinase-MB were significantly lower than the control group at 12h and 24h after PCI (P<0.01). The peak values of troponin-I in the treatment group were also lower than the control group at 8h after PCI (P<0.01). Multivariate regression analysis showed that L-carnitine therapy was an independent predictor for the reduction of creatine kinase-MB (r=0.596, P<0.001) or troponin-I (r=0.633, P<0.001).Conclusion: L-carnitine adjunct therapy appears to be associated with a reduced level of cardiac markers in patients with NSTEMI. These results support a larger clinical trial to investigate the effect of L-carnitine on cardiac events following PCI.
Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalCardiovascular Drugs and Therapy
Volume21
Issue number6
DOIs
Publication statusPublished - 2007

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Carnitine
Percutaneous Coronary Intervention
MB Form Creatine Kinase
Troponin I
Control Groups
Therapeutics
Acute Coronary Syndrome
Chest Pain
Non-ST Elevated Myocardial Infarction
Multivariate Analysis
Regression Analysis
Clinical Trials

Cite this

Xue, Yuzeng ; Wang, Lexin ; Liu, Hua-Zhi ; Qi, Xue-Wen ; Wang, Xiao-Hua ; Ren, Hai-Zhou. / L-carnitine as an adjunct therapy to percutaneous coronary intervention for Non-ST Elevation Myocardial Infarction. In: Cardiovascular Drugs and Therapy. 2007 ; Vol. 21, No. 6. pp. 445-448.
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abstract = "Objectives: To evaluate the effects of L-carnitine as an adjunct therapy to percutanenous coronary intervention (PCI) for non-ST elevation acute coronary syndrome (NSTEMI).Methods: Ninety-six consecutive patients with NSTEMI were randomized into treatment group (L-carnitine 5 g IV bolus followed by 10 g/day IV infusion for three days), and control group. All patients also underwent PCI within 24h from the onset of chest pain. The peak values of creatine kinase-MB and troponin-I before and after PCI were observed. Results: In the treatment group, the peak values of creatine kinase-MB were significantly lower than the control group at 12h and 24h after PCI (P<0.01). The peak values of troponin-I in the treatment group were also lower than the control group at 8h after PCI (P<0.01). Multivariate regression analysis showed that L-carnitine therapy was an independent predictor for the reduction of creatine kinase-MB (r=0.596, P<0.001) or troponin-I (r=0.633, P<0.001).Conclusion: L-carnitine adjunct therapy appears to be associated with a reduced level of cardiac markers in patients with NSTEMI. These results support a larger clinical trial to investigate the effect of L-carnitine on cardiac events following PCI.",
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L-carnitine as an adjunct therapy to percutaneous coronary intervention for Non-ST Elevation Myocardial Infarction. / Xue, Yuzeng; Wang, Lexin; Liu, Hua-Zhi; Qi, Xue-Wen; Wang, Xiao-Hua; Ren, Hai-Zhou.

In: Cardiovascular Drugs and Therapy, Vol. 21, No. 6, 2007, p. 445-448.

Research output: Contribution to journalArticle

TY - JOUR

T1 - L-carnitine as an adjunct therapy to percutaneous coronary intervention for Non-ST Elevation Myocardial Infarction

AU - Xue, Yuzeng

AU - Wang, Lexin

AU - Liu, Hua-Zhi

AU - Qi, Xue-Wen

AU - Wang, Xiao-Hua

AU - Ren, Hai-Zhou

N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Cardiovascular Drugs and Therapy. ISSNs: 0920-3206;

PY - 2007

Y1 - 2007

N2 - Objectives: To evaluate the effects of L-carnitine as an adjunct therapy to percutanenous coronary intervention (PCI) for non-ST elevation acute coronary syndrome (NSTEMI).Methods: Ninety-six consecutive patients with NSTEMI were randomized into treatment group (L-carnitine 5 g IV bolus followed by 10 g/day IV infusion for three days), and control group. All patients also underwent PCI within 24h from the onset of chest pain. The peak values of creatine kinase-MB and troponin-I before and after PCI were observed. Results: In the treatment group, the peak values of creatine kinase-MB were significantly lower than the control group at 12h and 24h after PCI (P<0.01). The peak values of troponin-I in the treatment group were also lower than the control group at 8h after PCI (P<0.01). Multivariate regression analysis showed that L-carnitine therapy was an independent predictor for the reduction of creatine kinase-MB (r=0.596, P<0.001) or troponin-I (r=0.633, P<0.001).Conclusion: L-carnitine adjunct therapy appears to be associated with a reduced level of cardiac markers in patients with NSTEMI. These results support a larger clinical trial to investigate the effect of L-carnitine on cardiac events following PCI.

AB - Objectives: To evaluate the effects of L-carnitine as an adjunct therapy to percutanenous coronary intervention (PCI) for non-ST elevation acute coronary syndrome (NSTEMI).Methods: Ninety-six consecutive patients with NSTEMI were randomized into treatment group (L-carnitine 5 g IV bolus followed by 10 g/day IV infusion for three days), and control group. All patients also underwent PCI within 24h from the onset of chest pain. The peak values of creatine kinase-MB and troponin-I before and after PCI were observed. Results: In the treatment group, the peak values of creatine kinase-MB were significantly lower than the control group at 12h and 24h after PCI (P<0.01). The peak values of troponin-I in the treatment group were also lower than the control group at 8h after PCI (P<0.01). Multivariate regression analysis showed that L-carnitine therapy was an independent predictor for the reduction of creatine kinase-MB (r=0.596, P<0.001) or troponin-I (r=0.633, P<0.001).Conclusion: L-carnitine adjunct therapy appears to be associated with a reduced level of cardiac markers in patients with NSTEMI. These results support a larger clinical trial to investigate the effect of L-carnitine on cardiac events following PCI.

KW - Open access version available

KW - L-carnitine

KW - Mortality.

KW - Myocardial infarction

KW - Percutaneous coronary intervention

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DO - 10.1007/s10557-007-6056-9

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JO - Cardiovascular Drugs and Therapy

JF - Cardiovascular Drugs and Therapy

SN - 0920-3206

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ER -