L-carnitine as an adjunct therapy to percutaneous coronary intervention for Non-ST Elevation Myocardial Infarction

Yuzeng Xue, Lexin Wang, Hua-Zhi Liu, Xue-Wen Qi, Xiao-Hua Wang, Hai-Zhou Ren

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Abstract

Objectives: To evaluate the effects of L-carnitine as an adjunct therapy to percutanenous coronary intervention (PCI) for non-ST elevation acute coronary syndrome (NSTEMI).Methods: Ninety-six consecutive patients with NSTEMI were randomized into treatment group (L-carnitine 5 g IV bolus followed by 10 g/day IV infusion for three days), and control group. All patients also underwent PCI within 24h from the onset of chest pain. The peak values of creatine kinase-MB and troponin-I before and after PCI were observed. Results: In the treatment group, the peak values of creatine kinase-MB were significantly lower than the control group at 12h and 24h after PCI (P<0.01). The peak values of troponin-I in the treatment group were also lower than the control group at 8h after PCI (P<0.01). Multivariate regression analysis showed that L-carnitine therapy was an independent predictor for the reduction of creatine kinase-MB (r=0.596, P<0.001) or troponin-I (r=0.633, P<0.001).Conclusion: L-carnitine adjunct therapy appears to be associated with a reduced level of cardiac markers in patients with NSTEMI. These results support a larger clinical trial to investigate the effect of L-carnitine on cardiac events following PCI.
Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalCardiovascular Drugs and Therapy
Volume21
Issue number6
DOIs
Publication statusPublished - 2007

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