TY - JOUR
T1 - Laboratory testing, diagnosis, and management of von Willebrand disease. Current practice in Australasia. RCPA Quality Assurance Program in Haematology Scientific Haemostasis Advisory Panel
AU - Favaloro, E J
AU - Smith, J
AU - Petinos, P
AU - Collecutt, M
AU - Street, A
AU - Hertzberg, M
PY - 1999/11
Y1 - 1999/11
N2 - We report an evaluation of current laboratory and clinical practice for the diagnosis and management of von Willebrand disease (VWD) for a wide geographic area including Australia, New Zealand, and parts of Southeast Asia. This assessment has been undertaken in conjunction with the RCPA Quality Assurance Program (QAP) in Haematology. This external QAP currently comprises around 550 participating laboratories, of which some 450 perform coagulation testing, and from which 32 laboratories were identified to be actively involved in testing for VWD. These laboratories were targeted and their current laboratory and clinical practice evaluated by using various questionnaires. Our overall findings indicate a wide variation in laboratory test practice for VWD-based investigations. There was considerable variation among laboratories in the tests and test methods used, the control and calibration material used, the reported test reference intervals and units used, and the composite test panels used to diagnose VWD. However, substantial consensus in the clinical evaluation process, as undertaken by hematologists, also was identified. Despite the observed variations, most laboratory professionals seemed to understand the complexities involved in the diagnosis and subclassification of VWD, and the laboratories can provide an effective diagnostic service.
AB - We report an evaluation of current laboratory and clinical practice for the diagnosis and management of von Willebrand disease (VWD) for a wide geographic area including Australia, New Zealand, and parts of Southeast Asia. This assessment has been undertaken in conjunction with the RCPA Quality Assurance Program (QAP) in Haematology. This external QAP currently comprises around 550 participating laboratories, of which some 450 perform coagulation testing, and from which 32 laboratories were identified to be actively involved in testing for VWD. These laboratories were targeted and their current laboratory and clinical practice evaluated by using various questionnaires. Our overall findings indicate a wide variation in laboratory test practice for VWD-based investigations. There was considerable variation among laboratories in the tests and test methods used, the control and calibration material used, the reported test reference intervals and units used, and the composite test panels used to diagnose VWD. However, substantial consensus in the clinical evaluation process, as undertaken by hematologists, also was identified. Despite the observed variations, most laboratory professionals seemed to understand the complexities involved in the diagnosis and subclassification of VWD, and the laboratories can provide an effective diagnostic service.
KW - Asia, Southeastern
KW - Australia
KW - Evaluation Studies as Topic
KW - Hematologic Tests/methods
KW - Humans
KW - Multicenter Studies as Topic
KW - New Zealand
KW - Practice Patterns, Physicians'
KW - Quality Assurance, Health Care
KW - Reference Values
KW - Surveys and Questionnaires
KW - von Willebrand Diseases/blood
KW - von Willebrand Factor/analysis
U2 - 10.1093/ajcp/112.5.712
DO - 10.1093/ajcp/112.5.712
M3 - Article
C2 - 10549259
SN - 0002-9173
VL - 112
SP - 712
EP - 719
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
IS - 5
ER -