Laboratory testing protocols for Heparin-Induced Thrombocytopenia (HIT) Testing

Kun Kan Edwin Lau, Soma Mohammed, Leonardo Pasalic, Emmanuel J Favaloro

Research output: Book chapter/Published conference paperChapter (peer-reviewed)peer-review

9 Citations (Scopus)


Heparin-induced thrombocytopenia (HIT) represents a significant high morbidity complication of heparin therapy. The clinicopathological diagnosis of HIT remains challenging for many reasons; thus, laboratory testing represents an important component of an accurate diagnosis. Although there are many assays available to assess HIT, these essentially fall into two categories-(a) immunological assays, and (b) functional assays. The current chapter presents protocols for several HIT assays, being those that are most commonly performed in laboratory practice and have the widest geographic distribution. These comprise a manual lateral flow-based system (STiC), a fully automated latex immunoturbidimetric assay, a fully automated chemiluminescent assay (CLIA), light transmission aggregation (LTA), and whole blood aggregation (Multiplate).

Original languageEnglish
Title of host publicationHemostasis and Thrombosis
Subtitle of host publicationMethods and Protocols
EditorsEmmanuel J. Favaloro, Giuseppe Lippi
Place of PublicationNew York
Number of pages17
ISBN (Electronic)9781493971961
Publication statusPublished - 14 Aug 2017

Publication series

NameMethods in Molecular Biology
PublisherHumana Press
ISSN (Print)1064-3745


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