Left ventricular ejection fraction determination in gated single photon emission computed tomography: 8 Versus 16 bin data

Nardia Poole, Janelle Wheat, Geoffrey Currie, Damien Coote

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Abstract

While Quantitative Gated SPECT (QGS) determined gated single photon emission computed tomography (SPECT) functional parameters have been previously validated, acquisition and processing parameters consistent with those utilised in validation studies are adhered to infrequently. The aim of this investigation was to determine the impact on left ventricular ejection fraction (LVEF) determination of 8 versus 16 bin data in post stress data. The gated stress studies of 160 patient files were examined. Each gated study was acquired using a 16 bin gated SPECT acquisition. On completion of the acquisition, the 16 bin data was reconstructed to produce short axis slices. The short axis slices were re-binned to produce 8 bin data which, with the 16 bin data, used QGS to generate functional data. The mean LVEF for the 16 bin data was 64.0% (95% CI 61.9-66.1%) and for the 8 bin data was 59.9% (95% CI 57.8-62.0%). Excellent correlation was demonstrated with a correlation coefficient of 0.99. The mean difference between matched pairs of 16 and 8 bin LVEF data was 4.1% (95% CI 3.8-4.5%). The matched pair t test demonstrated a statistically significant difference (P < 0.0001) and a statistically significant difference was shown between the means (P = 0.0002). The impact of performing 8 bin data collection results in a 4.1% underestimation of the stress LVEF due to temporal under-sampling. This approximates the 3.7% underestimation widely reported in the literature for post-filtered resting data although there is a statistically significant difference between matched pairs (P = 0.02). Using stress data does, however, require the same 4% LVEF correction recommended for rest data.
Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalANZ Nuclear Medicine
Volume37
Issue number2
Publication statusPublished - 2006

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