TY - JOUR
T1 - Levels of human immunodeficiency virus type 1 RNA in cerebrospinal fluid correlate with AIDS dementia stage
AU - Brew, Bruce J.
AU - Pemberton, Louise
AU - Cunningham, Phillip
AU - Law, Matthew G.
PY - 1997/1/1
Y1 - 1997/1/1
N2 - The relationship between the presence and severity of AIDS dementia complex (ADC) and the levels of human immunodeficiency virus type 1 (HIV-1) RNA in cerebrospinal fluid (CSF) were assessed. Nineteen patients with ADC (stages 1-3), 6 without ADC (group 1), and 10 (group 2) without ADC but with cryptococcal meningitis or progressive multifocal leukoencephalopathy were studied. There was a significant relationship between increasing CSF virus burden and ADC severity (P=.0006) but not with plasma burden and ADC severity. In group 2, CSF HIV-1 RNA levels in patients with cryptococcal meningitis were elevated. These results show that CSF HIV-1 RNA concentrations correlate well with ADC severity but may also be increased by central nervous system infections, such as cryptococcal meningitis.
AB - The relationship between the presence and severity of AIDS dementia complex (ADC) and the levels of human immunodeficiency virus type 1 (HIV-1) RNA in cerebrospinal fluid (CSF) were assessed. Nineteen patients with ADC (stages 1-3), 6 without ADC (group 1), and 10 (group 2) without ADC but with cryptococcal meningitis or progressive multifocal leukoencephalopathy were studied. There was a significant relationship between increasing CSF virus burden and ADC severity (P=.0006) but not with plasma burden and ADC severity. In group 2, CSF HIV-1 RNA levels in patients with cryptococcal meningitis were elevated. These results show that CSF HIV-1 RNA concentrations correlate well with ADC severity but may also be increased by central nervous system infections, such as cryptococcal meningitis.
UR - http://www.scopus.com/inward/record.url?scp=0030901509&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030901509&partnerID=8YFLogxK
U2 - 10.1086/514001
DO - 10.1086/514001
M3 - Article
C2 - 9086160
AN - SCOPUS:0030901509
SN - 0022-1899
VL - 175
SP - 963
EP - 966
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -