Limiting Factors in Self-paced Exercise Tolerance: the role of the neuroinflammation and central sensitisation

The thesis explores the role of different physiological systems within the body and how their complex interaction may contribute to feelings of fatigue during exercise. Specifically, the thesis is focused on interleukin-6 (IL-6), a biological marker which acts to signal a multitude of pathways at both local and systemic levels, including those to the brain. The release of IL-6 during exercise is well documented, however, has only recently been identified as a marker of fatigue. From a central perspective, the thesis looks to identify whether or not changes in brain waves during exercise, specifically in alpha and beta waves, are associated with feelings of fatigue or reductions in power output, and whether or not IL-6 is also implicated in this. Finally, the thesis explores a theory of acute central sensitisation during exercise and whether or not it is evident in changes in brain waves. This theory suggests that excitatory and inhibitory signalling can be altered due to afferent feedback from the periphery to the brain as exercise duration and/or intensities increase, and hence, lead to decreased performance and/or increased feelings of fatigue as an overall protective mechanism.