Liver biomarkers in diabetes mellitus, prediabetes and periodontal disease: evidence of triangular correlation

Eferhire Aganbi, Donald Effiong, Anayochukwu Anyasodor, Emmanuel Oluero, Mudiaga Itietie, Ezekiel Nwose

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Abstract

It is known that patients with fatty liver disease and periodontal disease (PD) are at risk for developing diabetes mellitus (DM) and vice versa. However, evidence of any triangular correlation as well as epidemiological data from rural communities of low-mid income countries. This study evaluated the correlation and differences in average levels of blood sugar, liver biomarkers and PD indices among patients attending orodental clinic Volunteer hospital clients were classified into prediabetes, prediabetes-PD, diabetic-PD and control. Blood glucose levels (BGL), lipid profile and orodental examinations were investigated. Analysis included correlation of BGL with clinical attachment loss (CAL) and gingival recession (GR); as well as liver biomarkers. Gender differences in all assessed parameters were also determined. Results showed that BGL in groups strongly correlates with levels of CAL (r = 0.74), GR depths (r = 0.72), serum protein (r = 0.88) and total bilirubin(r = 0.71). The PD indices also showed moderate to strong correlations with liver enzymes (r = 0.44), total bilirubin(r = 0.82) andserum protein(r = 0.60). Lipid profile was neither correlated nor significant, except total cholesterol being significantly higher in men (p < 0.01). Conclusion, there is considerable correlation between the triad of BGL, liver biomarkers and PD indices. This observation extends the knowledge of diabetesperiodontal two-way relationship to include liver functions. The non-significant higher dyslipidaemia in DMperiodontal co-morbidity relative to periodontal-prediabetes may indicate a pathophysiology different from nonperiodontal-prediabetes, but affirms implication of liver and oral health in diabetes pathogenesis.
Original languageEnglish
Article number2
Pages (from-to)39 - 46
Number of pages8
JournalWorld Journal of Medical Sciences
Volume14
Issue number2
Publication statusPublished - 2017

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Prediabetic State
Periodontal Diseases
Diabetes Mellitus
Biomarkers
Blood Glucose
Periodontal Index
Liver
Gingival Recession
Liver Diseases
Bilirubin
Hospital Volunteers
Lipids
Oral Health
Rural Population
Fatty Liver
Dyslipidemias
Blood Proteins
Cholesterol
Morbidity
Enzymes

Cite this

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title = "Liver biomarkers in diabetes mellitus, prediabetes and periodontal disease: evidence of triangular correlation",
abstract = "It is known that patients with fatty liver disease and periodontal disease (PD) are at risk for developing diabetes mellitus (DM) and vice versa. However, evidence of any triangular correlation as well as epidemiological data from rural communities of low-mid income countries. This study evaluated the correlation and differences in average levels of blood sugar, liver biomarkers and PD indices among patients attending orodental clinic Volunteer hospital clients were classified into prediabetes, prediabetes-PD, diabetic-PD and control. Blood glucose levels (BGL), lipid profile and orodental examinations were investigated. Analysis included correlation of BGL with clinical attachment loss (CAL) and gingival recession (GR); as well as liver biomarkers. Gender differences in all assessed parameters were also determined. Results showed that BGL in groups strongly correlates with levels of CAL (r = 0.74), GR depths (r = 0.72), serum protein (r = 0.88) and total bilirubin(r = 0.71). The PD indices also showed moderate to strong correlations with liver enzymes (r = 0.44), total bilirubin(r = 0.82) andserum protein(r = 0.60). Lipid profile was neither correlated nor significant, except total cholesterol being significantly higher in men (p < 0.01). Conclusion, there is considerable correlation between the triad of BGL, liver biomarkers and PD indices. This observation extends the knowledge of diabetesperiodontal two-way relationship to include liver functions. The non-significant higher dyslipidaemia in DMperiodontal co-morbidity relative to periodontal-prediabetes may indicate a pathophysiology different from nonperiodontal-prediabetes, but affirms implication of liver and oral health in diabetes pathogenesis.",
keywords = "Diabetes, Dyslipidaemia, Liver, Function, Tests, Periodontitis, Periodontal, Disease, Screening",
author = "Eferhire Aganbi and Donald Effiong and Anayochukwu Anyasodor and Emmanuel Oluero and Mudiaga Itietie and Ezekiel Nwose",
note = "Includes bibliographical references.",
year = "2017",
language = "English",
volume = "14",
pages = "39 -- 46",
journal = "World Journal of Medical Sciences",
issn = "1817-3055",
publisher = "International Digital Organization for Scientific Information",
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}

Liver biomarkers in diabetes mellitus, prediabetes and periodontal disease: evidence of triangular correlation. / Aganbi, Eferhire; Effiong, Donald ; Anyasodor, Anayochukwu; Oluero, Emmanuel ; Itietie, Mudiaga; Nwose, Ezekiel.

In: World Journal of Medical Sciences , Vol. 14, No. 2, 2, 2017, p. 39 - 46.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Liver biomarkers in diabetes mellitus, prediabetes and periodontal disease: evidence of triangular correlation

AU - Aganbi, Eferhire

AU - Effiong, Donald

AU - Anyasodor, Anayochukwu

AU - Oluero, Emmanuel

AU - Itietie, Mudiaga

AU - Nwose, Ezekiel

N1 - Includes bibliographical references.

PY - 2017

Y1 - 2017

N2 - It is known that patients with fatty liver disease and periodontal disease (PD) are at risk for developing diabetes mellitus (DM) and vice versa. However, evidence of any triangular correlation as well as epidemiological data from rural communities of low-mid income countries. This study evaluated the correlation and differences in average levels of blood sugar, liver biomarkers and PD indices among patients attending orodental clinic Volunteer hospital clients were classified into prediabetes, prediabetes-PD, diabetic-PD and control. Blood glucose levels (BGL), lipid profile and orodental examinations were investigated. Analysis included correlation of BGL with clinical attachment loss (CAL) and gingival recession (GR); as well as liver biomarkers. Gender differences in all assessed parameters were also determined. Results showed that BGL in groups strongly correlates with levels of CAL (r = 0.74), GR depths (r = 0.72), serum protein (r = 0.88) and total bilirubin(r = 0.71). The PD indices also showed moderate to strong correlations with liver enzymes (r = 0.44), total bilirubin(r = 0.82) andserum protein(r = 0.60). Lipid profile was neither correlated nor significant, except total cholesterol being significantly higher in men (p < 0.01). Conclusion, there is considerable correlation between the triad of BGL, liver biomarkers and PD indices. This observation extends the knowledge of diabetesperiodontal two-way relationship to include liver functions. The non-significant higher dyslipidaemia in DMperiodontal co-morbidity relative to periodontal-prediabetes may indicate a pathophysiology different from nonperiodontal-prediabetes, but affirms implication of liver and oral health in diabetes pathogenesis.

AB - It is known that patients with fatty liver disease and periodontal disease (PD) are at risk for developing diabetes mellitus (DM) and vice versa. However, evidence of any triangular correlation as well as epidemiological data from rural communities of low-mid income countries. This study evaluated the correlation and differences in average levels of blood sugar, liver biomarkers and PD indices among patients attending orodental clinic Volunteer hospital clients were classified into prediabetes, prediabetes-PD, diabetic-PD and control. Blood glucose levels (BGL), lipid profile and orodental examinations were investigated. Analysis included correlation of BGL with clinical attachment loss (CAL) and gingival recession (GR); as well as liver biomarkers. Gender differences in all assessed parameters were also determined. Results showed that BGL in groups strongly correlates with levels of CAL (r = 0.74), GR depths (r = 0.72), serum protein (r = 0.88) and total bilirubin(r = 0.71). The PD indices also showed moderate to strong correlations with liver enzymes (r = 0.44), total bilirubin(r = 0.82) andserum protein(r = 0.60). Lipid profile was neither correlated nor significant, except total cholesterol being significantly higher in men (p < 0.01). Conclusion, there is considerable correlation between the triad of BGL, liver biomarkers and PD indices. This observation extends the knowledge of diabetesperiodontal two-way relationship to include liver functions. The non-significant higher dyslipidaemia in DMperiodontal co-morbidity relative to periodontal-prediabetes may indicate a pathophysiology different from nonperiodontal-prediabetes, but affirms implication of liver and oral health in diabetes pathogenesis.

KW - Diabetes

KW - Dyslipidaemia

KW - Liver

KW - Function

KW - Tests

KW - Periodontitis

KW - Periodontal

KW - Disease

KW - Screening

M3 - Article

VL - 14

SP - 39

EP - 46

JO - World Journal of Medical Sciences

JF - World Journal of Medical Sciences

SN - 1817-3055

IS - 2

M1 - 2

ER -