Loop de loop: viral RNA evades IFIT1 targeting

Justin A Roby; Brian D Clarke; Alexander A Khromykh

doi:10.1016/j.tim.2014.02.014

Loop de loop: viral RNA evades IFIT1 targeting

Justin A Roby, Brian D Clarke, Alexander A Khromykh

Dentistry and Medical Sciences

University of Queensland

Research output: Contribution to journal › Project summary › peer-review

2 Citations (Scopus)

Abstract

In a landmark finding published in Science, Hyde et al. have demonstrated that a hairpin RNA structure adjacent to the 5' cap of alphavirus genomic RNA confers the ability of these viruses to evade restriction by the interferon-induced host protein IFIT1.

Original language	English
Pages (from-to)	171-3
Number of pages	3
Journal	Trends in Microbiology
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.tim.2014.02.014
Publication status	Published - Apr 2014

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title = "Loop de loop: viral RNA evades IFIT1 targeting",

abstract = "In a landmark finding published in Science, Hyde et al. have demonstrated that a hairpin RNA structure adjacent to the 5' cap of alphavirus genomic RNA confers the ability of these viruses to evade restriction by the interferon-induced host protein IFIT1. ",

keywords = "Alphavirus/pathogenicity, Alphavirus Infections/immunology, Animals, Host-Pathogen Interactions/immunology, RNA Caps/chemistry, RNA, Viral/chemistry",

author = "Roby, {Justin A} and Clarke, {Brian D} and Khromykh, {Alexander A}",

year = "2014",

month = apr,

doi = "10.1016/j.tim.2014.02.014",

language = "English",

volume = "22",

pages = "171--3",

journal = "Trends in Microbiology",

issn = "0966-842X",

publisher = "Elsevier",

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TY - JOUR

T1 - Loop de loop

T2 - viral RNA evades IFIT1 targeting

AU - Roby, Justin A

AU - Clarke, Brian D

AU - Khromykh, Alexander A

PY - 2014/4

Y1 - 2014/4

N2 - In a landmark finding published in Science, Hyde et al. have demonstrated that a hairpin RNA structure adjacent to the 5' cap of alphavirus genomic RNA confers the ability of these viruses to evade restriction by the interferon-induced host protein IFIT1.

AB - In a landmark finding published in Science, Hyde et al. have demonstrated that a hairpin RNA structure adjacent to the 5' cap of alphavirus genomic RNA confers the ability of these viruses to evade restriction by the interferon-induced host protein IFIT1.

KW - Alphavirus/pathogenicity

KW - Alphavirus Infections/immunology

KW - Animals

KW - Host-Pathogen Interactions/immunology

KW - RNA Caps/chemistry

KW - RNA, Viral/chemistry

U2 - 10.1016/j.tim.2014.02.014

DO - 10.1016/j.tim.2014.02.014

M3 - Project summary

C2 - 24630528

SN - 0966-842X

VL - 22

SP - 171

EP - 173

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 4

ER -

Loop de loop: viral RNA evades IFIT1 targeting

Abstract

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