TY - JOUR
T1 - Magnetic nanomaterial–based electrochemical biosensors for the detection of diverse circulating cancer biomarkers
AU - Koo, Kevin M.
AU - Soda, Narshone
AU - Shiddiky, Muhammad J.A.
N1 - Funding Information:
This work was supported by the Australian Research Council (ARC) Discovery Project Grant ( DP190102944 ) to M.J.A.S and Griffith University HDR International Postgraduate Research Scholarship (GUIPRS) to N.S.
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/2
Y1 - 2021/2
N2 - Electrochemical biosensors are highly compatible with modern advancements in magnetic nanomaterials. In particular, the versatile nature of magnetic nanomaterials as a universal platform for selective isolation of diverse forms of cancer biomarkers in body circulation, is highly synergistic with electrochemical biosensors for elevating biosensing performance to unprecedented levels. Such diverse circulating target biomolecules include cell surface proteins of circulating tumor cells and extracellular vesicles (EVs), as well as circulating tumor nucleic acids (i.e. ctDNA/ctRNA). This focussed review serves to discuss the latest work in the fields of magnetic nanomaterials and electrochemistry to tackle existing analysis challenges of diverse circulating biomarkers in cancer.
AB - Electrochemical biosensors are highly compatible with modern advancements in magnetic nanomaterials. In particular, the versatile nature of magnetic nanomaterials as a universal platform for selective isolation of diverse forms of cancer biomarkers in body circulation, is highly synergistic with electrochemical biosensors for elevating biosensing performance to unprecedented levels. Such diverse circulating target biomolecules include cell surface proteins of circulating tumor cells and extracellular vesicles (EVs), as well as circulating tumor nucleic acids (i.e. ctDNA/ctRNA). This focussed review serves to discuss the latest work in the fields of magnetic nanomaterials and electrochemistry to tackle existing analysis challenges of diverse circulating biomarkers in cancer.
KW - Cancer
KW - Circulating DNA/RNA
KW - Circulating tumor cells
KW - Electrochemical biosensors
KW - Exosomes
KW - Magnetic nanomaterials
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U2 - 10.1016/j.coelec.2020.100645
DO - 10.1016/j.coelec.2020.100645
M3 - Review article
AN - SCOPUS:85096536508
SN - 2451-9103
VL - 25
JO - Current Opinion in Electrochemistry
JF - Current Opinion in Electrochemistry
M1 - 100645
ER -
