TY - JOUR
T1 - Magnetophoretic separation of diamagnetic particles through parallel ferrofluid streams
AU - Munaz, Ahmed
AU - Shiddiky, Muhammad J.A.
AU - Nguyen, Nam Trung
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Particle separation based on microfluidic technology offers a simple, reliable, and low-cost approach for the diagnosis of diseases. The separation concept can be extended to genetic engineering, cell transplantation, and immunology. This paper reports a simple microfluidic platform for the separation of diamagnetic particles of different sizes utilizing parallel ferrofluid streams. The ferrofluid streams with predefined concentrations of magnetic nanoparticles promote negative magnetophoresis and are able to separate a particle mixture with a subtle size variation. Numerical simulation was used to optimise the magnetic field gradient, e.g. the number and position of the external permanent magnets. The effect of flow rate ratio and the concentration distribution were analyzed by the simulation and validated by experiments. Furthermore, two-stream and three-stream ferrofluid configurations were evaluated to find the optimum separation performance. The experimental results show a maximum separation efficiency of 78% and 75% with three-stream configuration for 3.2-μm and 4.8-μm particles, respectively.
AB - Particle separation based on microfluidic technology offers a simple, reliable, and low-cost approach for the diagnosis of diseases. The separation concept can be extended to genetic engineering, cell transplantation, and immunology. This paper reports a simple microfluidic platform for the separation of diamagnetic particles of different sizes utilizing parallel ferrofluid streams. The ferrofluid streams with predefined concentrations of magnetic nanoparticles promote negative magnetophoresis and are able to separate a particle mixture with a subtle size variation. Numerical simulation was used to optimise the magnetic field gradient, e.g. the number and position of the external permanent magnets. The effect of flow rate ratio and the concentration distribution were analyzed by the simulation and validated by experiments. Furthermore, two-stream and three-stream ferrofluid configurations were evaluated to find the optimum separation performance. The experimental results show a maximum separation efficiency of 78% and 75% with three-stream configuration for 3.2-μm and 4.8-μm particles, respectively.
KW - Ferrofluid
KW - Magnetofluidics
KW - Negative magnetophoresis
KW - Particle separation
UR - http://www.scopus.com/inward/record.url?scp=85052301447&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052301447&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2018.07.176
DO - 10.1016/j.snb.2018.07.176
M3 - Article
AN - SCOPUS:85052301447
SN - 0925-4005
VL - 275
SP - 459
EP - 469
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
ER -