Manipulating the Insulin Sensitivity of Insulin-Resistant Ponies

Kellie D. Tinworth

    Research output: ThesisDoctoral Thesis

    803 Downloads (Pure)


    These ponies have persistent IR that is resistant to dietary manipulation (without exercise), but they may also be able to adapt to high sugar diets over time, rather than entering a phase of escalating hyperinsulinaemia that could trigger laminitis. Their rapid adaptation/de-adaptation is more suggestive of a hormonal control mechanism than a change in tissue SI or gut morphology. Thus, the incretin effect is worth investigating further. The genetic attributes of these laminitis-resistant' animals also requires further consideration.However, the developmental period of laminitis may be prolonged in cases of pasture-associated laminitis and in the absence of histological examination of the lamellar tissues of the ponies' feet, the presence of dietary change in the integrity of the lamellar tissues cannot be discounted.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • Charles Sturt University
    • Noble, Glenys, Co-Supervisor
    • Sillence, Martin, Co-Supervisor
    • Harris, Pat, Co-Supervisor, External person
    Award date01 Mar 2012
    Place of PublicationAustralia
    Publication statusPublished - 2013


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