Mass mortality of Eastern Grey Kangaroos (Macropus giganteus) associated with hepatogenous photosensitisation subsequent to ingestion of Panicum gilvum

Research output: Other contribution to conferenceAbstract

Abstract

The impact of introduced toxic plant species, to which evolutionarily naïve native mammals have little tolerance, is poorly documented but is an emerging issue in wildlife population health. Blindness associated with photosensitivity, as well as abnormal behaviours including shade seeking in domestic buildings and straying onto roads and roadside verges resulted in subsequent mass mortalities of Eastern Grey Kangaroos (Macropus giganteus), which occurred in the Wagga Wagga region of New South Wales in April 2014. Necropsy of affected cases revealed lesions indicative of dermal and corneal photosensitivity. In particular, animals presented with marked corneal oedema with a ventral to dorsal progression indicative of progressive stages of the disease. Dermal and ocular lesions were associated with cholangiohepatopathy of varying severity and chronicity and hyperbilirubinaemia. This syndrome was suspected to be a plant toxicosis resulting in hepatogenous photosensitisation. The presence of acicular clefts in hepatic portal regions suggested saponin toxicity.
An analysis of pasture proportion and species indicated a high proportion a Panicum grass initially identified as Panicum gilvum. P. gilvum has been reported to contain steroidal saponins that have been implicated in crystalline hepatopathy and cholestasis resulting in photosensitivity in livestock. UPLC/QToF mass spectrometry indicated that steroidal saponins similar to diosgenin were found in the leaves, stems and inflorescence of P. gilvum. Trace metabolites were also evaluated in livers of affected kangaroos and are as yet unidentified. Subsequent outbreaks have occurred since 2013, highlighting the importance of understanding how invasive weeds species can adversely impact populations of native mammals.
Original languageEnglish
Pages42
Number of pages1
Publication statusPublished - 2018
Event10th International Symposium on Poisonous Plants : ISOPP 10 - Red Lion Conference Center, St George , United States
Duration: 16 Sep 201820 Sep 2018
https://conference.usu.edu/ISOPP/

Conference

Conference10th International Symposium on Poisonous Plants
CountryUnited States
CitySt George
Period16/09/1820/09/18
Internet address

Fingerprint

Macropus giganteus
Panicum
steroid saponins
ingestion
lesions (animal)
mammals
diosgenin
hyperbilirubinemia
cholestasis
abnormal behavior
liver
blindness
Macropodidae
saponins
New South Wales
edema
roads
poisoning
necropsy
wildlife

Cite this

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title = "Mass mortality of Eastern Grey Kangaroos (Macropus giganteus) associated with hepatogenous photosensitisation subsequent to ingestion of Panicum gilvum",
abstract = "The impact of introduced toxic plant species, to which evolutionarily na{\"i}ve native mammals have little tolerance, is poorly documented but is an emerging issue in wildlife population health. Blindness associated with photosensitivity, as well as abnormal behaviours including shade seeking in domestic buildings and straying onto roads and roadside verges resulted in subsequent mass mortalities of Eastern Grey Kangaroos (Macropus giganteus), which occurred in the Wagga Wagga region of New South Wales in April 2014. Necropsy of affected cases revealed lesions indicative of dermal and corneal photosensitivity. In particular, animals presented with marked corneal oedema with a ventral to dorsal progression indicative of progressive stages of the disease. Dermal and ocular lesions were associated with cholangiohepatopathy of varying severity and chronicity and hyperbilirubinaemia. This syndrome was suspected to be a plant toxicosis resulting in hepatogenous photosensitisation. The presence of acicular clefts in hepatic portal regions suggested saponin toxicity.An analysis of pasture proportion and species indicated a high proportion a Panicum grass initially identified as Panicum gilvum. P. gilvum has been reported to contain steroidal saponins that have been implicated in crystalline hepatopathy and cholestasis resulting in photosensitivity in livestock. UPLC/QToF mass spectrometry indicated that steroidal saponins similar to diosgenin were found in the leaves, stems and inflorescence of P. gilvum. Trace metabolites were also evaluated in livers of affected kangaroos and are as yet unidentified. Subsequent outbreaks have occurred since 2013, highlighting the importance of understanding how invasive weeds species can adversely impact populations of native mammals.",
keywords = "kangaroo, panicum, photosensitisation",
author = "Andrew Peters and Steventon, {Chloe A.} and Shane Raidal and Leslie Weston and Jane Quinn",
year = "2018",
language = "English",
pages = "42",
note = "10th International Symposium on Poisonous Plants : ISOPP 10 ; Conference date: 16-09-2018 Through 20-09-2018",
url = "https://conference.usu.edu/ISOPP/",

}

Peters, A, Steventon, CA, Raidal, S, Weston, L & Quinn, J 2018, 'Mass mortality of Eastern Grey Kangaroos (Macropus giganteus) associated with hepatogenous photosensitisation subsequent to ingestion of Panicum gilvum' 10th International Symposium on Poisonous Plants , St George , United States, 16/09/18 - 20/09/18, pp. 42.

Mass mortality of Eastern Grey Kangaroos (Macropus giganteus) associated with hepatogenous photosensitisation subsequent to ingestion of Panicum gilvum. / Peters, Andrew; Steventon, Chloe A.; Raidal, Shane; Weston, Leslie; Quinn, Jane.

2018. 42 Abstract from 10th International Symposium on Poisonous Plants , St George , United States.

Research output: Other contribution to conferenceAbstract

TY - CONF

T1 - Mass mortality of Eastern Grey Kangaroos (Macropus giganteus) associated with hepatogenous photosensitisation subsequent to ingestion of Panicum gilvum

AU - Peters, Andrew

AU - Steventon, Chloe A.

AU - Raidal, Shane

AU - Weston, Leslie

AU - Quinn, Jane

PY - 2018

Y1 - 2018

N2 - The impact of introduced toxic plant species, to which evolutionarily naïve native mammals have little tolerance, is poorly documented but is an emerging issue in wildlife population health. Blindness associated with photosensitivity, as well as abnormal behaviours including shade seeking in domestic buildings and straying onto roads and roadside verges resulted in subsequent mass mortalities of Eastern Grey Kangaroos (Macropus giganteus), which occurred in the Wagga Wagga region of New South Wales in April 2014. Necropsy of affected cases revealed lesions indicative of dermal and corneal photosensitivity. In particular, animals presented with marked corneal oedema with a ventral to dorsal progression indicative of progressive stages of the disease. Dermal and ocular lesions were associated with cholangiohepatopathy of varying severity and chronicity and hyperbilirubinaemia. This syndrome was suspected to be a plant toxicosis resulting in hepatogenous photosensitisation. The presence of acicular clefts in hepatic portal regions suggested saponin toxicity.An analysis of pasture proportion and species indicated a high proportion a Panicum grass initially identified as Panicum gilvum. P. gilvum has been reported to contain steroidal saponins that have been implicated in crystalline hepatopathy and cholestasis resulting in photosensitivity in livestock. UPLC/QToF mass spectrometry indicated that steroidal saponins similar to diosgenin were found in the leaves, stems and inflorescence of P. gilvum. Trace metabolites were also evaluated in livers of affected kangaroos and are as yet unidentified. Subsequent outbreaks have occurred since 2013, highlighting the importance of understanding how invasive weeds species can adversely impact populations of native mammals.

AB - The impact of introduced toxic plant species, to which evolutionarily naïve native mammals have little tolerance, is poorly documented but is an emerging issue in wildlife population health. Blindness associated with photosensitivity, as well as abnormal behaviours including shade seeking in domestic buildings and straying onto roads and roadside verges resulted in subsequent mass mortalities of Eastern Grey Kangaroos (Macropus giganteus), which occurred in the Wagga Wagga region of New South Wales in April 2014. Necropsy of affected cases revealed lesions indicative of dermal and corneal photosensitivity. In particular, animals presented with marked corneal oedema with a ventral to dorsal progression indicative of progressive stages of the disease. Dermal and ocular lesions were associated with cholangiohepatopathy of varying severity and chronicity and hyperbilirubinaemia. This syndrome was suspected to be a plant toxicosis resulting in hepatogenous photosensitisation. The presence of acicular clefts in hepatic portal regions suggested saponin toxicity.An analysis of pasture proportion and species indicated a high proportion a Panicum grass initially identified as Panicum gilvum. P. gilvum has been reported to contain steroidal saponins that have been implicated in crystalline hepatopathy and cholestasis resulting in photosensitivity in livestock. UPLC/QToF mass spectrometry indicated that steroidal saponins similar to diosgenin were found in the leaves, stems and inflorescence of P. gilvum. Trace metabolites were also evaluated in livers of affected kangaroos and are as yet unidentified. Subsequent outbreaks have occurred since 2013, highlighting the importance of understanding how invasive weeds species can adversely impact populations of native mammals.

KW - kangaroo

KW - panicum

KW - photosensitisation

M3 - Abstract

SP - 42

ER -