TY - JOUR
T1 - Metabolomics
T2 - the greatest omics of them all?
AU - Ryan, Danielle
AU - Robards, Kevin
N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Analytical Chemistry. ISSNs: 0003-2700;
PY - 2006
Y1 - 2006
N2 - Is metabolomics the greatest 'omics' of all? Certainly, it has been suggested that metabolomics may in fact provide the most 'functional' information of the omics technologies.1 This reflects the limitations associated with transcriptomics and proteomics; for example, changes in the transcriptome and proteome do not always result in altered biochemical phenotypes (the metabolome).1,2 Furthermore, the metabolome represents the final 'omic' level in a biological system, and metabolites represent functional entities, unlike messenger RNA molecules, which constitute the transcriptome.3 Metabolites thus have a clear function in the life of the biological system and are also contextual,3 reflecting the surrounding environment. The metabolome can thus be thought of as a looking glass, which if looked through can show information concerning the physiological, developmental, and pathological status of a biological system.
AB - Is metabolomics the greatest 'omics' of all? Certainly, it has been suggested that metabolomics may in fact provide the most 'functional' information of the omics technologies.1 This reflects the limitations associated with transcriptomics and proteomics; for example, changes in the transcriptome and proteome do not always result in altered biochemical phenotypes (the metabolome).1,2 Furthermore, the metabolome represents the final 'omic' level in a biological system, and metabolites represent functional entities, unlike messenger RNA molecules, which constitute the transcriptome.3 Metabolites thus have a clear function in the life of the biological system and are also contextual,3 reflecting the surrounding environment. The metabolome can thus be thought of as a looking glass, which if looked through can show information concerning the physiological, developmental, and pathological status of a biological system.
U2 - 10.1021/ac0614341
DO - 10.1021/ac0614341
M3 - Article
VL - 78
SP - 7954
EP - 7958
JO - Industrial And Engineering Chemistry Analytical Edition
JF - Industrial And Engineering Chemistry Analytical Edition
SN - 0003-2700
IS - 23
ER -