mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia

Martin Engel, Peta Snikeris, Natalie Matosin, Kelly Anne Newell, Xu Feng Huang, Elisabeth Frank

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

An imbalance of excitatory and inhibitory neurotransmission underlies the glutamate hypothesis of schizophrenia. Agonists of group II metabotropic glutamate receptors, mGluR2/3, have been proposed as novel therapeutic agents to correct this imbalance. However, the influence of mGluR2/3 activity on excitatory and inhibitory neurotransmitter receptors has not been explored.
Original languageEnglish
Pages (from-to)1349-59
Number of pages11
JournalPsychopharmacology
Volume233
Issue number8
DOIs
Publication statusPublished - Apr 2016

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