Microfluidic technology for the generation of cell spheroids and their applications

Raja K. Vadivelu, Harshad Kamble, Muhammad J.A. Shiddiky, Nam Trung Nguyen

Research output: Contribution to journalReview articlepeer-review

84 Citations (Scopus)
2 Downloads (Pure)


A three-dimensional (3D) tissue model has significant advantages over the conventional two-dimensional (2D) model. A 3D model mimics the relevant in-vivo physiological conditions, allowing a cell culture to serve as an effective tool for drug discovery, tissue engineering, and the investigation of disease pathology. The present reviews highlight the recent advances and the development of microfluidics based methods for the generation of cell spheroids. The paper emphasizes on the application of microfluidic technology for tissue engineering including the formation of multicellular spheroids (MCS). Further, the paper discusses the recent technical advances in the integration of microfluidic devices for MCS-based high-throughput drug screening. The review compares the various microfluidic techniques and finally provides a perspective for the future opportunities in this research area.
Original languageEnglish
Article number94
Pages (from-to)1-23
Number of pages23
Issue number4
Early online dateMar 2017
Publication statusPublished - Apr 2017


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