Microglia modelling and analysis using L-systems grammar

Herbert Jelinek, Audrey Karperien

Research output: Book chapter/Published conference paperConference paperpeer-review

4 Citations (Scopus)

Abstract

Medical image analysis requires in the first instance information on the extent of normal variation in a biological system in order to identify pathological changes. MicroMod is an L-systems based software package available through the World Wide Web that allows modelling of complex branching structures such as neurons and glia using deterministic or probabilistic algorithms. In addition, MicroMod includes software for assessing complex structures using methods such as fractal and lacunarity analysis. We demonstrated through fractal analysis of simulated microglia that MicroMod can be used for modelling and measuring different stages of microglial activation. The fractal dimensions of microglia visualised using histochemical techniques showed good agreement with our models made using MicroMod, and changes in complexity and heterogeneity as seen during activation and response to pathology were well emulated by modifying a few essential parameters (sub to parent branch length, sub to parent branch diameter, and sub branch number). These results indicate that MicroMod provides a useful adjunct to neuroscience research into understanding complex changes in structure associated with normal function and disease processes.
Original languageEnglish
Title of host publicationBIOSIGNALS 2008, First International Conference on Biomedical Electronics and Devices
Subtitle of host publication1st Proceedings
EditorsAna Fred, Joaquim Filipe, Hugo Gamboa
Place of PublicationFrankfurt
PublisherSpringer
Pages289-294
Number of pages6
Volume2
ISBN (Electronic)9783540922186
Publication statusPublished - 2008
EventInternational Conference on Bio-inspired Systems and Signal Processing - Fuchal, Madeira, Portugal, Portugal
Duration: 28 Jan 200831 Jan 2008

Conference

ConferenceInternational Conference on Bio-inspired Systems and Signal Processing
CountryPortugal
Period28/01/0831/01/08

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