Background: Lactoferrin (Lf) is an iron-binding, sialylated glycoprotein prevalent in milk, and known to have multifunctional health benefits. Its potential role in neurodevelopment and cognition remains unknown. Objective: To determine the functional effect and underlying molecular biochemical mechanism of milk lactoferrin on early brain development and cognitive function in postnatal piglets. Method: 3-day-old male piglets (n=33) were randomly allocated 2 groups with supplemented Lf at a dose level of 155 mg/kg/d for 38 days. Global gene expression profile and the selected target gene and protein expression were determined. Learning and memory were assessed using an eight-arm radial maze. Results: Dietary Lf enhanced the piglet learning speed and long-term memory. Several gene expression pathways associated with promoting neurodevelopment and cognitive functions in Lf treatment group were up-regulated in hippocampus. At least ten genes involved in the brain-derived neurotrophic factor (BDNF) signaling pathway in the hippocampus were affected. Conclusion: Dietary promotes early brain development and cognitive functions by up-regulating the BDNF signaling pathway in postnatal piglets.
|Title of host publication||Experimental Biology|
|Place of Publication||United States|
|Publisher||The FASEB Journal|
|Number of pages||1|
|Publication status||Published - 2014|
|Event||Annual meeting of American Society for Nutrition - San Diego USA, New Zealand|
Duration: 01 Apr 2014 → …
|Conference||Annual meeting of American Society for Nutrition|
|Period||01/04/14 → …|
Wang, B., Chen, Y., Zheng, Z., Zhu, X., Shi, Y., Tian, D., & Troy, F. (2014). Milk lactoferrin supplementation enhances early brain development and cognition in postnatal piglets. In Experimental Biology (Vol. 28, pp. 1045-1045). The FASEB Journal.