Milk lactoferrin supplementation enhances early brain development and cognition in postnatal piglets

Bing Wang, Yue Chen, Zhi Zheng, Xi Zhu, Yu Shi, Dan Tian, Frederic Troy

Research output: Book chapter/Published conference paperConference paper

Abstract

Background: Lactoferrin (Lf) is an iron-binding, sialylated glycoprotein prevalent in milk, and known to have multifunctional health benefits. Its potential role in neurodevelopment and cognition remains unknown. Objective: To determine the functional effect and underlying molecular biochemical mechanism of milk lactoferrin on early brain development and cognitive function in postnatal piglets. Method: 3-day-old male piglets (n=33) were randomly allocated 2 groups with supplemented Lf at a dose level of 155 mg/kg/d for 38 days. Global gene expression profile and the selected target gene and protein expression were determined. Learning and memory were assessed using an eight-arm radial maze. Results: Dietary Lf enhanced the piglet learning speed and long-term memory. Several gene expression pathways associated with promoting neurodevelopment and cognitive functions in Lf treatment group were up-regulated in hippocampus. At least ten genes involved in the brain-derived neurotrophic factor (BDNF) signaling pathway in the hippocampus were affected. Conclusion: Dietary promotes early brain development and cognitive functions by up-regulating the BDNF signaling pathway in postnatal piglets.
Original languageEnglish
Title of host publicationExperimental Biology
Place of PublicationUnited States
PublisherThe FASEB Journal
Pages1045-1045
Number of pages1
Volume28
Publication statusPublished - 2014
EventAnnual meeting of American Society for Nutrition - San Diego USA, New Zealand
Duration: 01 Apr 2014 → …

Conference

ConferenceAnnual meeting of American Society for Nutrition
CountryNew Zealand
Period01/04/14 → …

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Lactoferrin
Cognition
Milk
Brain
Brain-Derived Neurotrophic Factor
Hippocampus
Learning
Gene Expression
Long-Term Memory
Insurance Benefits
Transcriptome
Glycoproteins
Iron
Genes
Proteins

Cite this

Wang, B., Chen, Y., Zheng, Z., Zhu, X., Shi, Y., Tian, D., & Troy, F. (2014). Milk lactoferrin supplementation enhances early brain development and cognition in postnatal piglets. In Experimental Biology (Vol. 28, pp. 1045-1045). United States: The FASEB Journal.
Wang, Bing ; Chen, Yue ; Zheng, Zhi ; Zhu, Xi ; Shi, Yu ; Tian, Dan ; Troy, Frederic. / Milk lactoferrin supplementation enhances early brain development and cognition in postnatal piglets. Experimental Biology. Vol. 28 United States : The FASEB Journal, 2014. pp. 1045-1045
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abstract = "Background: Lactoferrin (Lf) is an iron-binding, sialylated glycoprotein prevalent in milk, and known to have multifunctional health benefits. Its potential role in neurodevelopment and cognition remains unknown. Objective: To determine the functional effect and underlying molecular biochemical mechanism of milk lactoferrin on early brain development and cognitive function in postnatal piglets. Method: 3-day-old male piglets (n=33) were randomly allocated 2 groups with supplemented Lf at a dose level of 155 mg/kg/d for 38 days. Global gene expression profile and the selected target gene and protein expression were determined. Learning and memory were assessed using an eight-arm radial maze. Results: Dietary Lf enhanced the piglet learning speed and long-term memory. Several gene expression pathways associated with promoting neurodevelopment and cognitive functions in Lf treatment group were up-regulated in hippocampus. At least ten genes involved in the brain-derived neurotrophic factor (BDNF) signaling pathway in the hippocampus were affected. Conclusion: Dietary promotes early brain development and cognitive functions by up-regulating the BDNF signaling pathway in postnatal piglets.",
author = "Bing Wang and Yue Chen and Zhi Zheng and Xi Zhu and Yu Shi and Dan Tian and Frederic Troy",
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Wang, B, Chen, Y, Zheng, Z, Zhu, X, Shi, Y, Tian, D & Troy, F 2014, Milk lactoferrin supplementation enhances early brain development and cognition in postnatal piglets. in Experimental Biology. vol. 28, The FASEB Journal, United States, pp. 1045-1045, Annual meeting of American Society for Nutrition, New Zealand, 01/04/14.

Milk lactoferrin supplementation enhances early brain development and cognition in postnatal piglets. / Wang, Bing; Chen, Yue; Zheng, Zhi; Zhu, Xi; Shi, Yu; Tian, Dan; Troy, Frederic.

Experimental Biology. Vol. 28 United States : The FASEB Journal, 2014. p. 1045-1045.

Research output: Book chapter/Published conference paperConference paper

TY - GEN

T1 - Milk lactoferrin supplementation enhances early brain development and cognition in postnatal piglets

AU - Wang, Bing

AU - Chen, Yue

AU - Zheng, Zhi

AU - Zhu, Xi

AU - Shi, Yu

AU - Tian, Dan

AU - Troy, Frederic

N1 - Imported on 03 May 2017 - DigiTool details were: publisher = United States: The FASEB Journal, 2014. Event dates (773o) = April 2014; Parent title (773t) = Annual meeting of American Society for Nutrition. ISSNs: 0892-6638;

PY - 2014

Y1 - 2014

N2 - Background: Lactoferrin (Lf) is an iron-binding, sialylated glycoprotein prevalent in milk, and known to have multifunctional health benefits. Its potential role in neurodevelopment and cognition remains unknown. Objective: To determine the functional effect and underlying molecular biochemical mechanism of milk lactoferrin on early brain development and cognitive function in postnatal piglets. Method: 3-day-old male piglets (n=33) were randomly allocated 2 groups with supplemented Lf at a dose level of 155 mg/kg/d for 38 days. Global gene expression profile and the selected target gene and protein expression were determined. Learning and memory were assessed using an eight-arm radial maze. Results: Dietary Lf enhanced the piglet learning speed and long-term memory. Several gene expression pathways associated with promoting neurodevelopment and cognitive functions in Lf treatment group were up-regulated in hippocampus. At least ten genes involved in the brain-derived neurotrophic factor (BDNF) signaling pathway in the hippocampus were affected. Conclusion: Dietary promotes early brain development and cognitive functions by up-regulating the BDNF signaling pathway in postnatal piglets.

AB - Background: Lactoferrin (Lf) is an iron-binding, sialylated glycoprotein prevalent in milk, and known to have multifunctional health benefits. Its potential role in neurodevelopment and cognition remains unknown. Objective: To determine the functional effect and underlying molecular biochemical mechanism of milk lactoferrin on early brain development and cognitive function in postnatal piglets. Method: 3-day-old male piglets (n=33) were randomly allocated 2 groups with supplemented Lf at a dose level of 155 mg/kg/d for 38 days. Global gene expression profile and the selected target gene and protein expression were determined. Learning and memory were assessed using an eight-arm radial maze. Results: Dietary Lf enhanced the piglet learning speed and long-term memory. Several gene expression pathways associated with promoting neurodevelopment and cognitive functions in Lf treatment group were up-regulated in hippocampus. At least ten genes involved in the brain-derived neurotrophic factor (BDNF) signaling pathway in the hippocampus were affected. Conclusion: Dietary promotes early brain development and cognitive functions by up-regulating the BDNF signaling pathway in postnatal piglets.

M3 - Conference paper

VL - 28

SP - 1045

EP - 1045

BT - Experimental Biology

PB - The FASEB Journal

CY - United States

ER -

Wang B, Chen Y, Zheng Z, Zhu X, Shi Y, Tian D et al. Milk lactoferrin supplementation enhances early brain development and cognition in postnatal piglets. In Experimental Biology. Vol. 28. United States: The FASEB Journal. 2014. p. 1045-1045