MLST and Whole-Genome-Based Population Analysis of Cryptococcus gattii VGIII Links Clinical, Veterinary and Environmental Strains, and Reveals Divergent Serotype Specific Sub-populations and Distant Ancestors

Carolina Firacative, Chandler Roe, Richard Malik, Kennio Ferreira-Paim, Patricia Escandón, Jane sykes, Laura Rocio Castañón-Olivares, Cudberto Contreras-Peres, Bianca Samayoa, Tania C Sorrell, Elizabeth Castaneda, Shawn Lockhart, David Engelthaler, Wieland Meyer

Research output: Contribution to journalArticle

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Abstract

The emerging pathogen Cryptococcus gattii causes life-threatening disease in immunocompetent and immunocompromised hosts. Of the four major molecular types (VGI-VGIV), the molecular type VGIII has recently emerged as cause of disease in otherwise healthy individuals, prompting a need to investigate its population genetic structure to understand if there are potential genotype-dependent characteristics in its epidemiology, environmental niche(s), host range and clinical features of disease.
Original languageEnglish
Article numbere0004861
Pages (from-to)1-31
Number of pages31
JournalPLoS Neglected Tropical Diseases
Volume11
DOIs
Publication statusPublished - 2016

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